Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1996-12-02
1998-05-12
Stanton, Brian R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
4351723, 424 91, A61K 4900, C12N 1500, C12N 1509
Patent
active
057508267
ABSTRACT:
A transgenic non-human animal with alterations in a bradykinin B2 receptor gene is prepared by introduction of a gene encoding an altered bradykinin B2 receptor into a host non-human animal.
REFERENCES:
Yang et al. 1992. Theriogenology 38(2): 315-335.
Perkins, Martin N. et al., Antinociceptive activity of the bradykinin B1 models of persistent hyperalgesia in the rat, Pain, vol. 53, pp. 191-197, 1993.
McEachern, Adrienne E., et al., Expression cloning of a rat B2 bradykinin receptor, Proc. Natl. Acad. Sci. USA, vol. 88, p. 7724-7728, 1991.
Burch and Axelrod, Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: Evidence for G protein regulation of phospholipase A2.
Strader, Catherine et al., Structural basis of B-adrenergic receptor function, The FASEB Journal, vol. 3, pp. 1825-1832, 1989.
Chartrain, Nicole et al., Molecular Cloning, Structure and Chromosomal Localization of the Human Inducible Nitric Oxide Synthase Gene, The Journal of Biological Chemistry, vol. 269, No. 9, pp. 6765-6772, 1994.
Rinas, Ursula, et al., Characterization of Recombinant Factor XIIIa Produced in Saccharomyces Cerevisiae, Biotechnology, pp. 543-546, 1990.
Perkins & Kelly, Induction of bradykinin B1 receptors in vivo in a model of ultra-violet irradiation-induced thermal hyperalgesia in the rat, Br. J. Pharmacol., vol. 110, pp. 1441-1444, 1993.
Schneck, Kathryn, et al., Bradykinin B1 receptors in rabbit aorta smooth muscle cells in culture, European J. of Pharmacol., vol. 266, pp. 277-282, 1994.
Tropea, Margaret et al., B1 and B2 kinin receptors on cultured rabbit superior mesenteric artery smooth muscle cells: receptor-specific stimulation of inositol phosphate formation and arachidonic acid release by des-arg-bradykinin an dbradykinin, Journal of Pharmacol. and Experimental Therapeutics, vol. 264, No. 2, pp. 930-937, 1993.
Horowitz, Burton et al., Synthesis and Assembly of Functional Mammalian Na, K-ATPase in Yeast, Journal of Biological Chemistry, vol. 265, No. 8, pp. 4189-4192, 1990.
Goldstein & Wall, Activation of Protein Formation and Cell Division by Bradykinin and Des-Arg9-bradykinin, The Journal of Biological Chemistry, vol. 259, No. 14, pp. 9263-9268, 1984.
Slivka and Insel, Phorbol Ester and Neomycin Dissociate Bradykinin Receptor-mediated Arachidonic Acid Release and Polyphosphoinositide Hydrolysis in Madin-Darby Canine Kidney Cells, Journal of Biological Chemistry, vol. 263, No. 29, pp. 14640-14647, 1988.
Phillips, Elsa et al., Expression of Functional Bradykinin Receptors in Xenopus Oocytes, Journal of Neurochemistry, vol. 58, No. 1, pp. 243-249, 1992.
Regoli and Barabe, Pharmacology of Bradykinin and Related Kinins, Pharmacological Reviews, vol. 32, No. 1, pp. 1-46, 1980.
Masu, Yasuo et al., cDNA cloning of bovine substance-K receptor through oocyte expression system, Nature, vol. 329, pp. 836-838, 1987.
Dray and Perkins, Bradykinin and inflammatory pain, J. Neurophysiol., vol. 63, pp. 256-272, 1993.
Couture, R. et al., Peptides and the human colon: an in vitro pharmacological study, Can. J. Physiol. Pharmacol., vol. 59, pp. 957-964 1981. European Journal of Pharmacology, vol. 205, pp. 217-218, 1991.
Regoli, Domenico et al., Conversion of kinins and their antagonists into B1 Receptor activators and blockers in isolated vessels, European Journal of Pharmacology, vol. 127, pp. 219-224, 1986.
Regoli, D. et al., Receptors for bradykinin in rabbit aortae, Can. J. Physiol. Pharmacol., vol. 55, pp. 855-867, 1977.
Regoli, D. et al., De novo formation of vascular receptors for bradykinin 1, Can. J. Physiol. Pharmacol, vol. 56, pp. 674-677, 1978.
Regoli, Domenico et al., Induction of B1-Receptors for kinins in the rabbit by a bacterial lipopolysaccharide, European Journal of Pharmacology, vol. 71, pp. 105-115, 1981.
Farmer, S.G. et al., Induction of vascular smooth muscle bradykinin B1 receptors in vivo during antigen arthritis, Agents and Actions, vol. 34, pp. 191-193, 1993.
Deblois, Denis et al., Effect of glucocorticoids, monokines and growth factors on the spontaneously developing responses of the rabbit isolated aorta to des-Arg9-bradykinin, Br. J. Pharmacol., vol. 93, pp. 969-977, 1988.
deBlois, Denis et al., Pulse exposure to protein synthesis inhibitors enhances vascular responses to des-Arg9-bradykinin: possible role of interleukin-1, Br. J. Pharmacol. vol. 103, pp. 1057-1066, 1991.
deBlois, Denis et al., Pharmacological modulation of the up-regulated responses to des-Arg9-bradykinin in vivo and in vitro, Immunopharmacology, vol. 17, pp. 187-198, 1989.
Burch, R.M. et al. The Kallikrein-kininogen-kinin system in chronic inflammation, Agents and Actions, vol. 27, 3/4, pp. 258-260, 1989.
Tiffany and Burch, Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages, vol. 247, No. 2, pp. 189-192, 1989.
Proud, David, Kinin formation: Mechanisms and role in inflammatory disorders, Ann. Rev. Immunol., vol. 6: pp. 49-83, 1988.
Rhaleb, N. et al., Receptors for kinins in isolated arterial vessels of dogs, European Journal of Pharmacology, vol. 162, p. 419-427.
Lortie, Mark et al., The role of B1-and B2-kinin receptors in the renal tubular and hemodynamic response to bradykinin, American Physiological Society, vol. 262, pp. R72-R76, 1992.
Powell, Steven J. et al., Human Bradykinin B2 Receptor: Nucleotide Sequence Analysis and Assignment to Chromosome 14, Genomics, vol. 15, pp. 435-438, 1993.
Hess, Fred J. et al., Cloning and Pharmacological Characterization of a Human Bradykinin (BK-2) Receptor, Biochemical and Biophysical Research Communications, vol. 184, No. 1, pp. 260-268, 1992.
Eggerickx, Dominique et al., Molecular Cloning, Functional Expression and Pharmacological Characterization of a Human Bradykinin B2 Receptor Gene, vol. 187, No. 3, pp. 1306-1313, 1992.
Giladi and Spindel, Simple Luminometric Assay to detect Phosphoinositol-Linked Receptor Expression in Xenopus Oocytes, vol. 10, No. 6, pp. 744-747, 1991.
Hock, F.J. et al., Hoe 140 a new potent and long acting bradykinin-anagonist: in vitro studies, J. Pharmacol., vol. 102, pp. 769-773, 1991.
Sandberg, Kathryn et al., Calcium mobilization by angiotensin II and nerotransmitter receptors expressed in Xenopus laevis oocytes, FEBS Letters, vol. 241, No. 1,2 pp. 177-180, 1988.
Huang, Ruey-Ruey C., et al., Identification of Allosteric Antagonists of Receptor-Guanine Nucleotide-Binding Protein Interactions, Molecular Pharmacology, vol. 37, pp. 304-310, 1989.
Kitts, Paul A. et al., Linearization of baculovirus DNA enhances the recovery of recombinant virus expression vectors, Nucleic Acids Research, vol. 18, No. 19, 1990.
Hess, Fred J. et al., Differential Pharmacology of Cloned Human and Mouse B2 Bradykinin Receptors, Molecular Pharmacology, vol. 45, pp. 1-8, 1993.
H. Baribault et al., Embryoic Stem Cell Culture and Gene Targeting in Transgenic Mice, Mol. Biol. 6: 481-492 (1989).
A. Bradley, Production and Analysis of Chimaeric Mice, IRL Press, 113-151 (1987).
A. Bradley et al., Modifying the Mouse: Design and Desire, Bio/Technology 10: 534-539 (1992).
A. Bradley et al. Formation of Gem-line Chimaeras From Embryo-derived Teratocarcinoma Cell Lines, Nature 309: 255-256 (1984).
C.A. Brenner et al., Genes for Extracellular Matrix-degrading Metalloproteinases and Their Inhibitor, TIMP, are Expressed During Early Mammalian Development, Genes & Development 3: 848-859 (1989).
M.R. Capecchi, Altering the Genome by Homologous Recombination, Science 244: 1288-1292 (1989).
M.R. Capecchi, The New Mouse Genetics: Altering the Genome by Gene Targeting, Trends in Genetics 5: 70-76 (1989).
G.A. Evans et al., High Efficiency Vectors for Cosmid Microcloning and Genomic Analysis, Gene 79: 9-20 (1989).
M.J. Evans et al., Establishment in Culture of Pluripotential Cells from Mouse Embroys, Nature 292: 154-156 (1981).
M.A. Frohman et al., Cut, Paste and Save: new Approaches to Altering Specific Genes in Mice, Cell 56: 145-147 (1989).
A. Gossler et al., Transgenesis By Means of Blastocyst-Derived Embryonic Stem Cell Lines, Proc. Natl. Acad. Sci., USA 83: 9065-9069 (1986).
R.
Borkowski Joseph A.
Chen Howard Y.
Hess John W.
Strader Catherine D.
Trumbauer Myrna E.
Merck & Co. , Inc.
Stanton Brian R.
Tribble Jack L.
Yablonsky Michael D.
LandOfFree
Bradykinin B2 receptor modified transgenic non-human animals does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bradykinin B2 receptor modified transgenic non-human animals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bradykinin B2 receptor modified transgenic non-human animals will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-981546