Bradykinin B 2 receptor antagonist peptide from amphibian skin

Details Bradykinin B 2 receptor antagonist peptide from amphibian skin Bradykinin B 2 receptor antagonist peptide from amphibian skin

2011-08-23

2011-08-23

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C530S300000, C530S328000, C424S009100, C424S450000, C424S489000

Reexamination Certificate

active

08003610

ABSTRACT:
A bradykinin B2-receptor antagonist peptide, kinestatin, isolated from toad (Bombina maxima) defensive skin secretion, and analogs thereof, is disclosed. The structure of kinestatin is pGlu-Leu/Ile-Pro-Gly-Leu/Ile-Gly-Pro-Leu/Ile-Arg-NH2. Also disclosed are kinestatin analogs, prodrugs including the peptides, fusion peptides and multimeric peptides including the peptide sequences, pharmaceutical compositions including kinestatin and analogs thereof, prodrugs, fusion and multimeric peptides thereof, nucleic acids encoding kinestatin and analogs thereof, and nucleic acids encoding the fusion and multimeric peptides. Kinestatin and analogs thereof (including the prodrugs and multimeric and/or fusion peptides) can be used to treat and/or prevent disorders associated with bradykinin, including cardiovascular disorders, inflammation, asthma, allergic rhinitis, pain, angiogenesis and the like.

REFERENCES:
patent: WO 86/07263 (1986-12-01), None
N. E. Rhaleb et al., “Structure-Activity Studies of Bradykinin and Related Peptides. B2-Receptor Antagonists”,Hypertension, 17(1): 107-115 (1991).
Tianbao Chen et al., “Kinestatin: A Novel Bradykinin B2 Receptor Antagonist Peptide From the Skin Secretion of the Chinese Toad, Bombina Maxima”,Regulatory Peptides, 116(1-3): 147-154 (2003).
R. Lai et al., “A Novel Bradykinin-Related Peptide From Skin Secretions of Toad Bombina Maxima and Its Precursor Containing Six Identical Copies of the Final Product”,Biochemical and Biophysical Research Communications, 286(2): 259-263 (2001).

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