Bradykinin-antagonists for the treatment of acute pancreatitis

Details Bradykinin-antagonists for the treatment of acute pancreatitis Bradykinin-antagonists for the treatment of acute pancreatitis

1994-04-22

1997-09-23

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Bradykinin; kallidin; related peptides

530328, 514 16, A61K 3808, C07K 718

Patent

active

056706197

ABSTRACT:
The invention relates to the use of bradykinin-antagonists of the formula

REFERENCES:
patent: 4693993 (1987-09-01), Stewart et al.
patent: 4801613 (1989-01-01), Stewart et al.
patent: 4923963 (1990-05-01), Stewart et al.
patent: 5162497 (1992-11-01), Coy et al.
Masuda, T., Chem. Abstracts 114:207931 (1991).
Leach, "Perspectives on Acute Pancreatitis", Scand J. Gasteroenterol, 27, Suppl, 192: 29-38. (1992).
Griesbacher et al, "Effects of the bradykinin antagonist, HOE 140, in experimental acute pancreatitis", Br. J. Pharmacol. 107, 356-360, 1992.
Knolle et al., "New and Highly Potent Bradykinin Antagonists," Proceedings of the 12th American Peptide Symposium, Jun., 1991, Cambridge, Mass., USA.
Smith et al., eds., 1992, pp. 113-114.
Wada et al., "Studies on Plasma Bradykinin Level in Rats with Experimental Acute Pancreatitis," Biological Abstracts, 90 (3):242 (1990).
Thompson, A.G., "Proteinase Inhibitors in Experimental and Clinical Pancreatitis", Chem. Abs. 69:85345p (1968).
Ohlsson et al., "Trypsin-induced release of bradykinin and of C3 fragments in man: clinical and experimental studies on the protective role of alpha-2-macroglobulin and aprotinin," Chem. Abs. 99:63645d (1983).
A.V. Suvernev, "On the Pathogenic Treatment of Acute Pancreatitis," Vestnik Khirurgii,126 (1):36-40 (1981).
Berg et al., Kinin Antagonist Does Not Protect Against the Hypotensive Response to Endotoxin, Anaphylaxis or Acute Pancreatitis, J. Pharmacology & Exp. Therapeutics, vol. 251 (2): 731-734 (1989).
Kyle et al., Probing the Bradykinin Receptor: Mapping the Geometric Topography Using Ethers of Hydroxyproline in Novel Peptides, J. Med. Chem., Vol. 34: 2649-2653 (1991).

Affiliated with

Also associated with

Rating

Bradykinin-antagonists for the treatment of acute pancreatitis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bradykinin-antagonists for the treatment of acute pancreatitis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bradykinin-antagonists for the treatment of acute pancreatitis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1939041