Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-05
1998-12-01
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 530314, 530328, 530402, 530408, 530807, 530816, 530815, A61K 3808, C07K 718
Patent
active
058439005
ABSTRACT:
The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component.
REFERENCES:
patent: 4618598 (1986-10-01), Conn
patent: 4894443 (1990-01-01), Greenfield et al.
patent: 5416191 (1995-05-01), Cheronis et al.
Calixto, et al., "Nonpeptide Bradykinin Antagonists," pp. 97-129 (1991).
Carr, "The Effect of Anti-Inflammatory Drugs on Increased Vascular Permeability Induced by Chemical Mediators," J. Pathology, 108, 1-14 (1972).
Cheronis, et al. "Bradykinin Antagonists: Synthesis and In Vitro Activity of Bissuccinimidoalkane Peptide Dimers," In: Recent Progress in Kinins, pp. 551-558 (1992).
Kodama, H, et al., "Dimerization of Neurokinin A and B COOH-Terminal Heptapeptide Fragments Enhanced the Selectivity for Tachykinin Receptor Subtypes," Euro. J. Pharmacol., 151, 317-320 (1988).
Stewart, J. M., et al., "Chemistry of Peptide B2 Bradykinin Antagonists," In: Bradykinin Antagonists--Basic and Clinical Research., Burch, R. M. (ed.), Marcel Dekker, Inc., pp.51-96 (1991).
Stewart, J. M., et al., "Bradykinin Chemistry: Agonists and Antagonists," In. Adv. Exp. Med. Biol., vol. 156, Fritz, H., (ed.), Plenum Press, New York, pp. 585-589 (1983).
Vavrek, R. J., et al., "Succinyl Bis-Bradykinins: Potent Agonists with Exceptional Resistance to Enzymatic Degradation," In: Peptides--Structure and Function, Hruby, V. J., et al., (eds.), Pierce Chemical Company, Rockford.
Cheronis John C.
Gyorkos Albert
Spruce Lyle W.
Whalley Eric T.
Borin Michael
Cortech Inc.
Tsang Cecilia J.
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