Bradykinin antagonists

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Bradykinin; kallidin; related peptides

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530328, 530402, 530408, 530807, 530815, 530816, 5483144, 548521, 435107, 435117, 435118, 435121, 435128, 435129, C07K 718, A61K 3800

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active

056355939

ABSTRACT:
A brandykinin antagonist of the formula:

REFERENCES:
patent: 4618598 (1986-10-01), Conn
patent: 4894443 (1990-01-01), Greenfield et al.
patent: 5416191 (1995-05-01), Cheronis et al.
Vaverk et al., `Suyccinyl Bis-Bradykinins: Potent Agonists with Exceptional Resistance to Enzymatic Degradation`, Peptide: Struc. and Func., Proceedings of the 8th Amer. Pept. Symp., Pierce Chem. Co., Rockford, IL, pp. 381-384 1983.
Stewart et al., "Bradyinin Chemistry: Agonists and Antagonist", Advances in Experimental Medicine and Biology, Plenum Press, NY, NY pp. 585-589 1983.
Calixto et al., `Nonpeptide Bradykinin Antagonist`, Bradykinin Antagonists: Basic and Clinical Research, Ronald Burch (Ed.), Marcel Dekker Inc., NY, NY, pp. 97-129 1991.
Stewart et al., "Bradykinin Chemistry: Agonists and Antagonist", Advances in Experimental Medicine and Biology; Plenum Press, NY, NY (1983) pp. 585-589.
Vavrek et al, "Succinyl Bis-Bradykinins:Potent Agonists with Except. Resist. to Enzymatic Degradation", Peptide: Struc. and Func, Proceedings of the 8th Amer. Peptide Symposium, Pierce Chem.Co, Rockford, IL (1983)pp. 381-384.
Bradykinin Antagonists: Basic and Clinical Research, Ronald Burch (Ed.), Marcel Dekker Inc., NY, NY, pp. 52-81.

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