Bradykinin antagonist pseudopeptide derivatives of substituted 4

Details Bradykinin antagonist pseudopeptide derivatives of substituted 4 Bradykinin antagonist pseudopeptide derivatives of substituted 4

1995-04-03

1997-03-11

Lukton, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 17, 530314, 530328, A61K 3808

Patent

active

056101422

ABSTRACT:
Novel compounds with as few as three natural amino acids that incorporate a substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoyl bridge in place of selected fragments of peptidic bradykinin receptor antagonists are pseudopeptides with potent bradykinin receptor antagonist actions. These pseudopeptides and their pharmaceutical compositions are of benefit in treating conditions and diseases of mammals, including humans, in which an excess of bradykinin or a related kinin is produced endogenously or is received exogenously, for example via insect bite.

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