Bradykinin antagonist pseudopeptide derivatives of olefinic amin

Details Bradykinin antagonist pseudopeptide derivatives of olefinic amin Bradykinin antagonist pseudopeptide derivatives of olefinic amin

1993-09-09

1995-08-22

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 530329, 530332, 530314, 530323, A61K 3808

Patent

active

054440483

ABSTRACT:
Pseudopeptide compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acids at postions 2 through 5 are replaced by olefinic aminoalkenoyl groups to reduce the peptidic nature of the compounds.
The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.

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