Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Bradykinin; kallidin; related peptides
Patent
1994-07-28
1996-07-30
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Bradykinin; kallidin; related peptides
530329, 530330, A61K 3808
Patent
active
055412866
ABSTRACT:
Pseudopeptide compounds based on a modified bradykinin sequence are potent bradykinin receptor antagonists. Amino acids at at positions 2 through 5 are replaced by olefinic aminoalkenoyl groups to reduce the peptide nature of the compounds.
The analogs produced are useful in treating conditions and diseases of a mammal and human in which an excess of bradykinin or related kinins are produced or injected such as by insect bites.
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Lukton David
Schain Howard E.
Scios Nova Inc.
Shearer Peter R.
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