Bradykinin antagonist peptides incorporating N-substituted glyci

Details Bradykinin antagonist peptides incorporating N-substituted glyci Bradykinin antagonist peptides incorporating N-substituted glyci

1996-06-20

1997-12-23

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 21, 530314, 530327, 530328, C07K 718

Patent

active

057007799

ABSTRACT:
The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin including pain and inflammation.

REFERENCES:
patent: 4242329 (1980-12-01), Claeson et al.
patent: 4693993 (1987-09-01), Stewart et al.
Raymond J. Vavrek, et al., "Bradykinin Antagonists do not Require a D-aromatic Amino Acid Residue at Position 7", In Recent Progress on Kinins (Bonner G. et al. eds.) Agents and Actions Supplementas 38 (I), Birkhauser: BAsel., 572-581, (1992).
J. D. Young, et al., "Multi-Year, Multi-Center Evaluation of Solid-Phase Peptide Synthesis", 13th American Peptide Symposium, Edmonton, Albert, Canada, 1088-1090, (Jun. 20, 1993).

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