Bradykinin antagonist peptides containing indane-substituted ami

Details Bradykinin antagonist peptides containing indane-substituted ami Bradykinin antagonist peptides containing indane-substituted ami

1994-11-18

1997-07-15

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530327, 530328, 530326, 530314, 514 13, A61K 3800, C07K 706, C07K 1400

Patent

active

056483368

ABSTRACT:
The present invention pertains to modified bradykinin antagonist peptides of the formula X-A.sup.0 -B.sup.1 -C.sup.2 -D.sup.3 -E.sup.4 -F.sup.5 -G.sup.6 -H.sup.7 -J.sup.8 -K.sup.9, where at least one of F.sup.5, H.sup.7 and J.sup.8 is an indane substituted amino acids.

REFERENCES:
patent: 4693993 (1987-09-01), Stewart et al.
patent: 4923963 (1990-05-01), Stewart et al.
patent: 5416191 (1995-05-01), Cheronis et al.
Wilhelm, Annual Review of Medicine, vol. 22, 1971, pp. 63-84.
Polosa, Allergy, 1993, 48, pp. 217-225.
Hargreaves, et al, Clin Pharmacol Ther, Dec. 1988, pp. 613-621.
J. M. Stewart, et al., "Peptides 1992", ESCOM, C.H. Schneider and A.N. Eberle, eds., Leiden, 691-692, (1993).
Vavrek, et al., Peptides, 6, 161-164, (1985).
Zeitlin, et al., Gut, 14, 133, (1973).

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