Bradykinin antagonist peptides

Details Bradykinin antagonist peptides Bradykinin antagonist peptides

1987-09-02

1990-05-08

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Bradykinin; kallidin; related peptides

514803, 530327, 530328, C07K 718

Patent

active

049239635

ABSTRACT:
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aliphatic, cyclic or aromatic amino acid of the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists including C-terminal and N-terminal extensions and replacement of arginine in the one and nine positions which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mannal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.

REFERENCES:
patent: 3364193 (1968-01-01), Hernpel et al.
patent: 4399124 (1983-08-01), Fauve
patent: 4693993 (1987-09-01), Stewart et al.
Chem. Abstracts, vol. 101, 1984, 84128n.
Chem. Abstracts, vol. 103, 1985, 98853y.
Chem. Abstracts, vol. 105, 1986, 184127n.

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