Bradykinin antagonist peptides

Details Bradykinin antagonist peptides Bradykinin antagonist peptides

1985-06-13

1987-09-15

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 530314, 530327, 530328, C07K 3742, C07K 718, C07K 706, C07K 708

Patent

active

046939938

ABSTRACT:
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.

REFERENCES:
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Chem. Abstr., vol. 94, (1981) 202885.
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Chem. Abstr., vol. 83, (1975) 126640.
Chem. Abstr., vol. 89, (1978) 17275d.
Chem. Abstr., vol. 92, (1980) 122284.

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