Bradykinin antagonist peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 15, 530314, 530327, 530328, C07K 3742, C07K 718, C07K 706, C07K 708

Patent

active

046939938

ABSTRACT:
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.

REFERENCES:
Chem. Abstr., vol. 101, (1984) 84128n.
Chem. Abstr., vol. 88, (1978) 105763w.
Chem. Abstr., vol. 83, (1975) 10811t.
Can. J. Biochem., vol. 57, (1979) 1084-1089.
Chem. Abstr., vol. 93, (1980) 186777g.
Chem. Abstr., vol. 91, (1979) 168871.
Chem. Abstr., vol. 94, (1981) 202885.
Chem. Abstr., vol. 81, (1974) 9976c.
Chem. Abstr., vol. 83, (1975) 126640.
Chem. Abstr., vol. 89, (1978) 17275d.
Chem. Abstr., vol. 92, (1980) 122284.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Bradykinin antagonist peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bradykinin antagonist peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bradykinin antagonist peptides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1385067

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.