Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Bradykinin; kallidin; related peptides
Patent
1995-05-12
2000-06-13
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Bradykinin; kallidin; related peptides
530328, 530402, 514 15, 514 2, C07K 718, A61K 3808
Patent
active
060751207
ABSTRACT:
A bradykinin antagonist of the formula:
REFERENCES:
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Cheronis et al, "Bradykinin antagonists: Synthesis and in vitro Activity of Bissuccinimidoalkane Peptide Dimers" Recent Progress on Kinins, (1992) pp. 551-558.
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Vaverk et al., `Suyccinyl Bis-Bradykinins: Potent Agonists with Exceptional Resistance to Enzymatic Degradation`, Peptide: Struc. and Func., Proceedings of the 8th Amer. Pept. Symp., Pierce Chem. Co., Rockford, IL, pp. 381-384 1983.
Stewart et al., Bradykinin Chemistry: Agonists and Antagonist, Advances in Experimental Medicine and Biology, Plenum Press, NY, NY pp. 585-589 1983.
Calixto et al., `Nonpeptide Bradykinin Antagonist`, Bradykinin Antagonists: Basic and Clinical Research, Ronald Burch (Ed.), Marcel Dekker Inc., NY, NY, pp. 97-129 1991.
Kodama et al., `Dimerization of neurokinin A and B COOH- terminal heptapeptide fragments enhanced the selectivity for tachykinin receptor subtypes`, European Journal of Pharmacology, 151, pp. 317-320 1988.
Blodgett James K.
Cheronis John C.
Goodfellow Val Smith
Marathe Manoj Vinayak
Spruce Lyle W.
Cortech Inc.
Gupta Anish
Tsang Cecilia J.
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