Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-01-03
2006-01-03
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S013800, C514S014800, C514S015800, C514S016700, C514S017400, C514S018700, C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C530S329000
Reexamination Certificate
active
06982249
ABSTRACT:
The present invention provides bradykinin peptide analogs, compositions, and methods of inhibiting thrombin-induced platelet and other cell activation. The bradykinin analogs comprise single or multiple peptide segments. The invention also provides a method for identifying compounds that selectively inhibit thrombin-induced platelet and other cell activation.
REFERENCES:
patent: 4585757 (1986-04-01), Pang et al.
patent: 4638047 (1987-01-01), Szelke et al.
patent: 4693993 (1987-09-01), Stewart et al.
patent: 4870017 (1989-09-01), Ben-Bassat et al.
patent: 4923963 (1990-05-01), Stewart et al.
patent: 5231080 (1993-07-01), Scholkens
patent: 5300490 (1994-04-01), Kunihiro et al.
patent: 5350578 (1994-09-01), Griffin et al.
patent: 5385889 (1995-01-01), Kyle et al.
patent: 5409899 (1995-04-01), Fauchere et al.
patent: 5416191 (1995-05-01), Cheronis et al.
patent: 5446131 (1995-08-01), Maraganore
patent: 5472945 (1995-12-01), Schmaier et al.
patent: 5489575 (1996-02-01), Lee et al.
patent: 5607676 (1997-03-01), Gevas et al.
patent: B-39431/89 (1990-05-01), None
patent: WO 92/17201 (1991-10-01), None
patent: WO 94/11021 (1994-05-01), None
patent: WO/96/41640 (1996-12-01), None
Websters II, New Riverside University Dictionary 1259 (Anne H. Soukhanov ed., The Riverside Publishing Co. 1984).
Stewart et al., “Bradykinin Chemistry: Agonists and Antagonists”. In: Advance in Experimental Medicine and Biology,New York: Plenum Press, p. 585-589 (1983).
Martin et al., “Bradykinin Stimulates Phosphodiesteratic Cleavage of Phosphatidylcholine in Cultured Endothelial Cells”,Biochemical and Biophysical Research Communication, 157(3): 1271-1279 (1988).
Chem abstr., vol. 107, No. 17, Oct. 26, 1987 (Columbus, Ohio), p. 146, column 2, the abstract No. 148141v, Alheid et al., “Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets.”Thromb Res., 47(5): 561-71 (1987).
Chem. abstr., vol. 84, No. 21, May 24, 1976 (Colombus. Ohio), p. 417, column 2, the abstract No. 148985e, Shikawa et al., “Prostaglandin synthetase activity and hormone responsiveness in normal and SV40 transformed WI-38 fibroblasts”,J. of Cyclin Nucleotide Res., 2(2): 115-28 (1976).
Database CAplus on STN, Chemical Abstracts Service, (Columbus, OH), CAplus No. 1996:519830,Hasanet al., “Brandykinin and its metabolite, Arg-Pro-Pro-Gly-Phe, are selective inhibitors of alpha-thrombin-induced platelet activation”, abstract Circulation 1996.
Chem. abstr., vol. 111, No. 9, Aug. 28, 1989 (Columbus, Ohio), p. 178, column 2, the abstract No. 71858g, Loeb et al., “Endotherlium-dependent potentiation of human platelet aggregation”,Thromb. Res., 54(5): 477-86 (1989).
Chem. abstr., vol. 93, No. 25, Dec. 22, 1980 (Columbus Ohio), p. 100, column 1, the abstract No. 231243t, Imai et al., “Effects of prostacyclin on platelet aggregation as studied with ‘filter-loop’ technique in the flowing blood of the dog”,Artery, 8(1): 90-5 (1980).
Ngo et al., “Computational Complexity Protein Structure Problem and the Levinthal Paradox”,The Protein Folding Prediction and Tertiary Structure Prediction, pp. 491-495 (1994).
Hasan, et al., “The Carboxyl Terminus of Bradykinin and Amino Terminus of the Light Chain of Kininogens Comprise and Endothelial Cell Binding Domain”,The Journal of Biological Chemistry, 269(50): 31822-31830 (Dec. 16, 1994).
Wirth, et al., “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies”,British Journal of Pharmacology, 102(3): 774-777 (Mar., 1991).
Vu, et al., “Molecular Cloning of a Functional Thrombin Receptor Reveals a Novel Protelytic Mechanism of Receptor Activation”,Cell, 64: 1057-1068 (Mar. 22, 1991).
Puri, et al., “Inhibition of Thrombin-Induced Platelet Aggregation By High Molecular Weight Kininogen”,Transactions of the Association of American Physicans, C: 232-240 (1987).
Puri, et al., “Cleavage of A 100 kDa Membrane Protein (Aggregin) During Thrombin-Induced Platelet Aggregation Is Mediated By The High Affinity Thrombin Receptors”,Biochemical and Biophysical Research Communications, 162(3): 1017-1024 (Aug. 15, 1989).
Puri, et al., “Reocclusion after thrombolytic therapy: strategies for inhibiting thrombin-induced platelet aggregation”,Blood Coagulation and Fibrinolysis, 4: 465-478 (1993).
Puri, et al., “High Molecular Weight Kininogen Inhibits Thrombin-Induced Platelet Aggregation and Cleavage of Aggregin by Inhibiting Binding of Thrombin to Platelets”,Blood, 77(3): 500-507 (Feb. 1, 1991).
Meloni, et al., “Low Molecular Weight Kininogen Binds to Platelets to Modulate Thrombin-Induced Platelet Activation”,The Journal of Biological Chemistry, 265(11): 6786-6794 (Apr. 13, 1991).
Hasan et al., “Bradykinin And Related Peptides Selectively Inhibit α-Thrombin's Ability To Activate The Platelet Thrombin Receptor”,Thrombosis and Haemostasis, 73(6): 94 (Abstract) (Jun., 1995).
Imai, et al. “Effects of Prostacyclin on Plateet Aggregation as Studied With “Filter Loop” Technique in the Flowying of Blood of the Dog”,Artery8(1): 63-72 (1980).
J.A. Parsons, “Peptide Hormones”, published 1976 by University park Press (Baltimore), p. 1-7.
Park et al., “Synthesis of Peptides by the Solid Phase Method, III. Bradykinin: Fragments and Analogs”,Can. J. Biochem., 56: 92-100 (1978).
Hasan et al., “Bradykinin and Its Metabolite, Arg-Pro-Pro-Gly-Phe, Are Selective Inhibitors of α-Thrombin-Induced Platelet Activation”,Circulation, 94(3): 517-528 (Aug 1, 1996).
Hasan Ahmed A. K.
Schmaier Alvin H.
Campell Bruce R.
Drinker Biddle & Reath LLP
Gupta Anish
The Regents of the University of Michigan
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