BR*-diagnostics for monoamine receptors

Details BR*-diagnostics for monoamine receptors BR*-diagnostics for monoamine receptors

1989-06-26

1993-09-07

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 546 68, 435 721, A61K 4300, C07D45704, C12Q 100

Patent

active

052426785

ABSTRACT:
Compounds of general Formula I labeled with 7.sup.5 Br, .sup.76 Br, .sup.77 Br, .sup.80m Br or .sup.80 Br isotopes ##STR1## wherein R.sup.6 is a C.sub.1-6 hydrocarbon residue and C.sub.2 C.sub.3, C.sub.9 C.sub.10 is a single or a double bond, as well as their acid addition salts, as diagnostic media to image dopamine.

REFERENCES:
patent: 3920664 (1975-11-01), Clemens et al.
patent: 3959288 (1976-05-01), Bach et al.
patent: 4054660 (1977-10-01), Clemens et al.
patent: 4199579 (1980-04-01), Ferrari et al.
patent: 4299836 (1981-11-01), Mago nee Karacsony et al.
patent: 4417051 (1983-11-01), Sauer
patent: 4695635 (1987-09-01), Sauer et al.
patent: 5158957 (1992-10-01), Brumby et al.
Maziere et al., ".sup.76 Br Bromolisuride: A New Radiopharmacentical for in Vivo Studies", J. Biophys Biom (Sep. 15, 1986), 10 (2 Supp), p. 25.6 (CA 106:1536a).
Maziere et al., "In Vivo Quantitative Imaging of Dopamine Receptors in Human Brain Using Positron Emission Tomography and .sup.76 Br Bromospiperone," European Journal of Pharmacology, 114, pp. 267-272 (1985).
Maziere et al., ".sup.76 Br Bromolisuride: A New Tool for Quantitative In Vivo Imaging of D-2 Dopamine Receptors," European Journal of Pharmacology, 127, pp. 239-247 (1986).
Maziere et al., ".sup.76 Br-Bromospiroperidol: A New Tool for Quantitative In Vivo Imaging of Neuroleptic Receptors," Life Sciences, vol. 35, pp. 1349-1356 (1984).
Kung et al., "Synthesis and Biodistributionof Neutral Lipid-Soluble Tc-99m Complexes that Cross the Blood-Brain Barrier," J. Nucl. Med. 25:326-332 (1984).
Kung et al., "Synthesis of New Bis (aminoethanethiol) (BAT) Derivatives: Possible Ligands for .sup.99m Tc Braim Imaging Agents," Journal of Medicinal Chemistry, 28, 1280-1284 (1985).
Phelps et al., "Positron Emission Tomography: Human Brain Function and Biochemistry", Science, vol. 228, No 4701, pp. 799-809 (May 17, 1985).

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