BPI-immunoglobulin fusion proteins

Details BPI-immunoglobulin fusion proteins BPI-immunoglobulin fusion proteins

1993-05-19

1997-07-01

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4352523, 4351723, 4353201, 435 691, 5303873, 536 234, C12N 1512, C12N 1500, A61K 39395, C07K 1900

Patent

active

056435703

ABSTRACT:
Disclosed are novel hybrid fusion proteins comprising at their amino terminus, bactericidal/permeability-increasing protein or a biologically active fragment thereof and, at their carboxy terminus, at least one immunoglobulin heavy chain constant domain useful in treating bacterial infection. Also disclosed are DNA sequences encoding such proteins, recombinant methods for production of the proteins, and pharmaceutical preparations containing the recombinant products.

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