Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-08-23
2011-08-23
Yu, Misook (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
08003758
ABSTRACT:
Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC-1, particularly including prostate cancer and bladder cancer. In human normal tissues, BPC-1 is only expressed in certain tissues of the brain. However, BPC-1 is expressed at high levels in prostate cancer cells and is also expressed in bladder cancer cells. The structure of BPC-1 includes a signal sequence and a CUB domain. BPC-1 protein is secreted. Preliminary experimental evidence suggests that BPC-1 is directly involved in oncogenesis or maintenance of the transformed phenotype of cancer cells expressing BPC-1. BPC-1 also appears to bind specifically to a cellular protein expressed in prostate cancer cells and other cells.
REFERENCES:
patent: 6030793 (2000-02-01), Coffey et al.
patent: 1033401 (2000-09-01), None
patent: WO-92/01936 (1992-02-01), None
patent: WO-97/39139 (1997-10-01), None
patent: WO-00/09691 (2000-02-01), None
patent: WO-02/059275 (2002-08-01), None
patent: WO-02/090504 (2002-11-01), None
patent: WO-03/027228 (2003-04-01), None
Gura, Science, 1997, 278:1041-1042.
Kaiser, Science, 2006, 313, 1370.
Johnson and Tracey, ‘Peptide and Protein Drug Delivery’, In: Encyclopedia of Controlled Drug Delivery, vol. 2, 1999, pp. 816-833.
Granziero et al., Eur. J. Immunol. 1999, 29:1127-1138.
Byers, T., CA Journal, vol. 49, No. 6, Nov./Dec. 1999.
Bellone et al., Immunology Today, 1999, 20:457-462.
Ben-Efraim, Tumor Biology 1999; 20: 1-24.
Frazer, I., Expert. Opin. Pharmacother. 2004; 5: 2427-2434.
Alberts et al., Molecular Biology of the Cell, 3rd edition (1994) p. 465.
Bork and Beckmann, J. Mol. Biol. (1993) 231:539-545.
Bork et al., Trends in Genetics (1996) 12:425-427.
Bork, Genome Research (2000) 10:398-400.
Brenner, Trends in Genetics (1999) 15:132-133.
Bussemakers et al., Cancer Res (1991) 51:606-611.
Cheng and Flanagan, Cell (1994) 79:157-168.
Denmeade et al., Prostate (2001) 48:1-6.
Diatchenko et al., Proc. Natl. Acad. Sci. USA (1996) 93:6025-6030.
Doerks et al., Trends in Genetics (1998) 14:248-250.
Gaiger et al., Blood (2000) 96:1480-1489.
Garattini, Annals of Ocology (2003) 14:813-816.
Greenbaum et al., Genome Biology (2003) 4(9):117.2-117.8.
Hanke et al., Protein Sci (1996) 5:72-82.
Hillier et al., The WashU-Merck EST Project, Jul. 16, 1999, XP-002132401, Acc. No. AA013000.
Horoszewicz et al., Cancer Res. (1983) 43:1809.
Hubert et al., The Prostate (1999) 38(4):343.
Klein et al., Nature Med. (1997) 3:402-408.
Kuang et al., Nucleic Acids Res (1998) 26(4):1116-1123.
Lugo and Witte, Molec. Cell. Biol. (1989) 9:1263-1270.
Morton and Myszka, Methods in Enzymology (1998) 295:268.
Nemeth et al., Journal of Molecular Endocrinology (1998) 20:151-156.
Notice of Reasons for Rejection for Japanese Patent Application No. 2000-565126, mailed on Dec. 17, 2008, 3 pages.
Raitano and Korc, J. Biol. Chem. (1990) 265:10466-10472.
Reiter et al., Proc. Natl. Acad. Sci. USA (1998) 95:1735-1740.
Scott et al., Nature Genetics (1999) 21:440-443.
Shimizu-Nishikawa et al., Mol Brain Res (1995) 28:201-210.
Sjogren, Immunotechnology (1997) 3:161-172.
Skolnick et al., Trends in Biotech (2000) 18:34-39.
Smith et al., Nature Biotechnology (1997) 15:1222-1223.
Tockman et al., Cancer Res. (1992) 52:2711s-2718s.
Welford, Opt. Quant. Elect. (1991) 23:1.
Afar Daniel E.
Hubert Rene S.
Jakobovits Aya
Leong Kahan
Raitano Arthur B.
Agensys, Inc.
Halvorson Mark
Morrison & Foerster / LLP
Yu Misook
LandOfFree
BPC-1: a secreted brain-specific protein expressed and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with BPC-1: a secreted brain-specific protein expressed and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and BPC-1: a secreted brain-specific protein expressed and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2704693