Bp 50-specific antibodies and fragments thereof

Details Bp 50-specific antibodies and fragments thereof Bp 50-specific antibodies and fragments thereof

1993-09-20

1998-07-28

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303882, 53038822, 5303887, 5303871, 435332, 435334, 435343, 4353431, C07K 1618, C07K 1628, C12N 512

Patent

active

057864560

ABSTRACT:
A new B-cell receptor, Bp50, a 50 kilodalton polypeptide, that functions in B-cell proliferation is described. Ligands such as lymphokines, antibody molecules or the Fv fragments of antibody molecules that bind to Bp50 and augment the proliferation of activated B-cells can be used to regulate B-cell proliferation or differentiation.

REFERENCES:
Clark et al. Tissue Antigens 35: 33-36(1990).
Marshall et al. J. Clin. Immunol. 13: 165-174(1993).
Watson et al Recombinant DNA 2.sup.nd Ed. Scientific American Books, W H. Freeman & Co N.Y. 1992 pp. 79-98.
Ruitt et al, Immunology C. V. Mosby Co. & St. Louis, 1985 pp. 1.5, 5.7, & 2 pages in Glossary.
Stamenkovic et al, EMBO J. 8(5): 1403-1410, 1989.
Paulie et al; Cancer Immunol Immunother 17: 173-179, 1984.
Muraguchi et al, J. Exp Med 161:181-197, 1985.
Ambrus et al, J. Clin Invest. 75: 732-739, 1985.

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