Bowman-birk inhibitor concentrate compositions and methods for t

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

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514783, A61K 3578

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active

055059465

ABSTRACT:
A composition containing a Bowman-Birk Inhibitor Concentrate (BBIC) for the treatment of pre-malignant tissue is provided. Methods of using this composition in the prevention of cancer are also provided.

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Baturay et al., "Pyrene Acts as a Cocarcinogen with the Carcinogens Benzo[A]pyrene, .beta.-Propiolactone and Radiation in the Induction of Malignant Transformation in Cultured Mouse Fibroblasts; Soybean Extract Containing the Bowman-Birk Inhibitor Acts as an Anticarcinogen", Cell Biology and Toxicology 1986, 2, 21-32.
Birk et al., "Bull. Res. Council Israel" 1962, Sec. 1, 11, 48.
Birk et al., "Separation of a Tribolium-protease inhibitor from soybeans on a calcium phosphate column", Biochim. Biophys. Acta 1963, 67, 326.
Bowman, "Differentiation of Soy Bean Antitrypic Factors", Proc. Soc. Exptl. Med. 1946, 63, 547.
Hwang et al., "Purification, Partial Characterization and Immunological Relationships of Multiple Low Molecular Weight Protease Inhibitors of Soybean", Biochim. Biophys. Acta 1977, 495, 369-382.
Kennedy et al., "Anticarcinogenic Actions of Protease Inhibitors", Anticarcinogenesis and Radiation Protection, edited by Cerutti et al., Plenum Pub. Co., pp. 285-295 (1987).
Messadi et al., "Inhibition of Oral Carcinogenesis by a Protease Inhibitor", JNCI 1986, 76, 447-452.
Perlmann et al., Methods in Enzymology Volume XIX, "Bowman-Birk Inhibitor from Soybeans (Inhibitor AA)", 1970, 19, 860-861.
St. Clair et al., "Suppression of Dimethylhydrazine-induced Carcinogenesis in Mice by Dietary Addition of the Bowman-Birk Protease Inhibitor", Cancer Res. 1990, 50, 580-586.
Weed et al., "Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing the Bowman-Birk protease inhibitor", Carcinogenesis 1985, 6, 1239-1241.
Yavelow et al., "Bowman-Birk Soybean Protease Inhibitor as an Anticarcinogen", Cancer Res. 1983, 43, 2454-2459.
Yavelow et al., "Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro", Proc. Natl. Acad. Sci. USA 1985, 82, 5395-5399.

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