Bovine pancreatic trypsin inhibitor derived inhibitors of factor

Details Bovine pancreatic trypsin inhibitor derived inhibitors of factor Bovine pancreatic trypsin inhibitor derived inhibitors of factor

1993-07-01

1998-09-15

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530350, 514 12, C07K 1481, A61K 3855

Patent

active

058079807

ABSTRACT:
Compounds derived from BPTI which inhibit factor VIIa-TF complex with an inhibition constant of less than 500 nM, their pharmaceutical compositions, and methods of use. Also disclosed are isolated nucleic acid segments encoding for the compounds, vectors comprising the nucleic acid segment and promoter, transformed host cells, and a method for preparing the compounds using transformed host cells.

REFERENCES:
patent: 4966852 (1990-10-01), Wun et al.
patent: 4994372 (1991-02-01), Tabor et al.
patent: 5032573 (1991-07-01), Auerswald et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5106833 (1992-04-01), Broze, Jr. et al.
patent: 5118668 (1992-06-01), Auerswald et al.
Hynes, T.R. et al. (Oct. 1990) "X-ray crystal structure of the protease inhibitor domain of Alzhemier's amyloid beta-protein precursor" Biochem. 29(43):10009-10140.
Hoad and Geczy, 136 J. Immun. Methods 269, 1991.
Roberts et al., 89 Proc. Natl. Acad. Sci. USA 2429, 1992.
Goldenberg and Creighton, 179 J. Mol. Biol. 527, 1984.
Stanssens et al., Nucleic Acids Research 17:4441-4454 (1989).
Girard et al., Nature, 338:518-520 (1989).
Fritz et al., Arzneim.-Forsch/Drug Res., 33:479-494 (1983).
Bode et al., Eur. J. Biochem., 144:185-190 (1984).
Vedvick et al., J. Indus. Microbiol., vol. 7 (1991), pp. 197-201.
Creighton et al., Trends in Biochemical Sciences, vol. 14 (Aug. 1989), pp. 319-324.
Schulz et al., "Principles of Protein Structure", published 1979 by Springer-Verlag (N.Y.), pp. 14-16.
Schecter et al., Biochem. Biophys. Res. Commun., 27:157 (1967).
Laskowski et al., J. Ann. Rev. Biochem., 49:593:626 (1980).
Callander et al., J. Biol. Chem., 267:876-882 (1992).
Parmley et al., Gene, 73:305-318 (1988).
Mackie et al., Blood Reviews, 3:237-250 (1989).
Remington's Pharmaceutical Sciences, Mack Publishing Co. (A.R. Gennaro edit. 1985).
Yanish-Perron et al., Gene, 33:103-199 (1985).
Bullock et al., Biotechniques, 5:376-379 (1987).
Marks et al., J. Biol. Chem., 261:7115-7118 (1986).
Goldenberg, Biochemistry, 27:2481-2489 (1988).
Vieira et al., Meth. in Enzymol., 153:3-11 (1987).
Sambrook et al., Molecular Cloning-A Laboratory Manual, Cold Spring Harbor Laboratory Press, p. 4.29 (1989).
Weislander, Anal. Biochem., 98:305-309 (1979).
Wu et al., Oligonucleotide Synthesis-a Practical Approach, IRL Press Oxford and Washington, D.C., pp. 135-151 (Ed. Gait, M.J. 1984).
Zell et al., The EMBO Journal, 6:1809-1815 (1987).
Zacher III et al., Gene, 9:127-140 (1980).
Kunkel, Proc. Natl. Acad. Sci. USA, 82:488-492 (1985).
Cwirla et al., Proc. Natl. Acad. Sci. USA, 87:6378-6382 (1990).
Harlow et al., Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory (1988).
Clements et al., Gene, 106:267-272 (1991).
Beguin et al., Thromb. Haemost., 68:136-142 (1992).

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