Bovine P-selectin glycorpotein ligand-1

Details Bovine P-selectin glycorpotein ligand-1 Bovine P-selectin glycorpotein ligand-1

2006-08-30

2010-10-05

Landsman, Robert (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S069100, C435S069700, C514S002600, C530S350000, C530S387100, C530S387700

Reexamination Certificate

active

07807636

ABSTRACT:
A novel bovine P-selectin glycoprotein ligand-1 (bPSGL-1) is disclosed having the amino acid sequence set forth in SEQ. ID. NO:1. DNA sequences encoding the bPSGL-1 are also disclosed, along with vectors, host cells, and methods of using the bPSGL-1. The invention further provides methods for preventing or reducing acute inflammatory response in a bovine subject by administering bPSGL-1 and fragments thereof (e.g., a bPSGL-1 Ig fusion protein). The invention also provides methods for identifying compounds of reducing or preventing damage to tissue or organs caused by acute inflammatory response in a bovine.

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