Bovine nuclear transplantation

Details Bovine nuclear transplantation Bovine nuclear transplantation

1990-10-16

1991-10-15

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4351723, 800 2, 800DIG6, 935 53, 935111, C12N 1500

Patent

active

050574205

ABSTRACT:
A process to produce viable bovine embryos through nuclear transplantation. The process utilizes nuclear material from 4 cell and later stage developed embryos recovered from inseminated donor cows through nonsurgical or surgical means. Recipient eggs or oocytes are recovered and a portion of the ooplasm removed by micromanipulation. Individually separated cells from the nuclear material donor embryo are inserted into the recipient oocyte. The oocyte fragment and nuclear donor material are electrofused. The embryo is cultured in vitro, transferred for an interim time to a sheep oviduct and then transferred to a cow for gestation.

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Nuclear Transplantation in Sheep Embryos, S. M. Willadsen, Nature, vol. 320, No. 6057, pp. 63-65, Mar. 6, 1986.

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