Bovine interleukin-1.alpha.

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 70, 4351721, 4351723, 4352528, 435256, 435320, 536 27, 530350, 935 18, 935 28, 935 29, 935 41, 935 56, 935 58, 935 63, 935 69, 935 73, 935 82, C12N 118, C12N 100, C12N 1500, C12N 122, C12P 2100, C12P 2102, C07H 1512, C07K 1300

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048943339

ABSTRACT:
Cloning and expression of DNA segments encoding bovine IL-.alpha., and processes for producing purified bovine IL-1.alpha. as a product of recombinant cell culture, are disclosed.

REFERENCES:
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Oppenheim et al., "There is More Than One Interleukin 1", Immunol. Today 7:45 (1986).
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March et al., "Cloning, Sequence and Expression of Two Distinct Human Interleukin-1 Complementary DNAs", Nature 315:641 (1985).
Gubler et al., "Recombinant Human Interleukin 1a: Purification and Biological Characterization", J. Immunol. 136:2492 (1986).
Tocci et al., "Expression in Escherichia Coli of Fully Active Recombinant Human IL-1B: Comparison with Native Human IL-1B", J. Immunol. 138:1109 (1987).
Lomedico et al., "Cloning and Expression of Murine Interleukin-1 cDNA in Escherichia Coli", Nature 312:458 (1984).
Saklatvala et al., "Pig Interleukin 1", J. Exp. Med. 162:1208 (1985).

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