Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2006-10-24
2006-10-24
Winkler, Ulrike (Department: 1648)
Chemistry: molecular biology and microbiology
Vector, per se
C424S207100, C435S005000, C435S069100, C435S091200, C435S455000, C435S456000, C435S465000, C536S023400, C536S023720, C536S024100, C536S024200
Reexamination Certificate
active
07125712
ABSTRACT:
This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.
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Berkowitz Robert David
Kaleko Michael
Luo Tianci
Bell Boyd & Lloyd
Novartis AG
Winkler Ulrike
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