Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1993-03-22
1995-10-31
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
424813, 530395, 435 693, A61K 39245, C07K 1403
Patent
active
054627346
ABSTRACT:
A vaccination kit and protocol for using it are disclosed which results in immunity from infection by herpesvirus. A first formulation of an isolated viral glycoprotein is injected intramuscularly to result in systemic immunity. Later a second formulation including the isolated viral glycoprotein with an adjuvant is administered intranasally, or otherwise administered to the mucosal membranes. A level of both systemic and mucosal immunity is achieved such that viral infection, as well as symptomatic disease, is avoided. The method and the vaccine are exemplified by a vaccine for Bovine Herpesvirus 1.
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Israel Barbara A.
Letchworth, III Geoffrey J.
Krsek-Staples Julie
Nucker Christine M.
Wisconsin Alumni Research Foundation
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