Bovine GRF

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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2601125R, C07C10352, A61K 3702

Patent

active

045857563

ABSTRACT:
The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Asn-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu -Gln-Gly-Ala-Lys-Val-Arg-Leu-Y wherein Y is OH or NH.sub.2. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically. The peptides are useful in stimulating the release of GH so as to accelerate growth in warm-blooded non-human animals, particularly cattle, and/or to increase the production of milk in lactating cows, and also in improving aquiculture.

REFERENCES:
patent: 2595278 (1952-05-01), Maxwell
Krulich et al., Endocrinology, 83, 783-790 (1968).
Sykes et al., Biochem. J., 209, 643-651 (1983).
Rivier et al., 8th American Peptide Symposium, May 22-27, 1983, Tucson, Ariz., p. 237.
Rivier et al., Nature, vol. 300, 1982, pp. 276-278.
Bohlen et al., Biochemical and Biophysical Research Communications, 114, No. 3, 930-936 (1983).
Esch et al., Biochemical and Biophysical Research Communications, 109, No. 1, 152-158 (1982).
Guillemin et al., Science, 218, 585-587 (1982).
Esch et al., The Journal of Biological Chemistry, 258, No. 3, 1806-1812 (1983).
Spiess et al., Nature, 303, 532-535 (1983).

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