Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-03-27
2007-03-27
Kaushal, Sumesh (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100
Reexamination Certificate
active
10429979
ABSTRACT:
The present invention relates to a bovine VDJ cassette (BF1H1) that provides the novel ability to develop chimeric immunoglobulin molecule capable of incorporating both linear T cell epitope(s) (CDR1H and CDR2H) as well as conformational B cell epitope(s) (exceptionally long CDR3H). Further, multiple epitopes can be incorporated for development of multivalent vaccine by replacing at least a portion of an immunoglobulin molecule with the desired epitope such that functional ability of both epitope(s) and parent VDJ rearrangement is retained. The antigenized immunoglobulin incorporating both T and B epitopes of interest is especially useful for development of oral vaccines for use in humans apart from other species including cattle. The long CDR3H in BF1H1 VDJ rearrangement originates from long germline D-genes. The novel bovine germline D-genes provide unique molecular genetic marker for sustaining the D-gene pool in cattle essential for immunocompetence via selective breeding. D-gene specific DNA probe permits typing and selection of breeding cattle stock for maximum gemline D gene pool for better health and disease prevention. The bovine D-genes are unique to cattle and, therefore, provide sensitive and specific forensic analytical tool using molecular biology techniques to determine tissues suspected of bovine origin.
REFERENCES:
Saini, S.S. 1999. Molecular immunogenetics of bovine antibody. Ph D Thesis, University of Guelph.
Shojaei, F. 2001. Molecular aspects of bovine DH genes. MSc Thesis, University of Guelph.
Saini, S.S. , Allore B., Jacobs, R.M. and Kaushik, A. 1999. Exceptionally long CDR3H region with multiple cysteine residues in functional bovine IgM antibodies. European Journal of Immunology. 29: 2420-26.
Saini, S.S. and Kaushik, A. 2002. Extensive CDR3H length heterogeneity exists in bovine foetal VDJ rearrangements. Scandinavian Journal of Immunology. 55:140-48.
Kaushik Azad Kumar
Saini Surinder Singh
Shojaei Farbod
Bereskin & Parr
Gravelle Micheline
Kaushal Sumesh
Montanari David A.
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