Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1985-06-20
1990-09-11
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530820, 530839, 530827, 435 694, C07K 1506
Patent
active
049564552
ABSTRACT:
Substantially pure bovine pituitary fibroblast growth factor, a 146 amino acid residue polypeptide, is produced. The amino acid residue sequence of bpFGF is disclosed as well as a DNA chain encoding the polypeptide. By appropriately inserting a synthesized DNA chain into a cloning vector and using the cloning vector to transform cells, synthetic bpFGF can be obtained from transformed cell lines, both prokaryotic and eukaryotic.
REFERENCES:
"Purification and Partial Characterization of an . . . Pituitary", Gambarini et al., JBC 257(16) 1982, pp. 9692-9697.
"Purification in High Yield of Brain Fibroblast Growth Factor . . . pH 9.6", JBC 257(20) 1982, pp. 1226-1276, Gospodarowicz et al.
"Brain Derived Fibroblast Growth Factor . . . Myelin", PNAS 75(10) 1978, pp. 4675-4678, Westall et al.
Baird Andrew
Bohlen Peter
Esch Frederick S.
Gospodarowicz Denis
Ling Nicholas C.
Draper Garnette D.
The Salk Institute for Biological Studies
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