Bovine .beta.-mannosidase nucleic acid sequence

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 221, 536 243, 536 2431, 536 2433, 435 5, 435 6, 435 912, C07H 2102, C07H 2104, C12Q 168, C12P 1934

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058378367

ABSTRACT:
The gene encoding bovine .beta.-mannosidase has been identified, cloned, sequenced and characterized. The full-length cDNA contains 3852 nucleotides encoding 879 amino acids. The mutation involved in bovine .beta.-mannosidosis has also been identified. Oligonucleotides and antibodies raised to the gene product are provided and are used in a variety of methods including assays to screen for an abnormal .beta.-mannosidase gene and diagnosis of .beta.-mannosidosis.

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