Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...
Patent
1997-03-13
2000-07-11
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant virus encoding one or more heterologous proteins...
4242051, 4242331, 424 932, 4352351, 4353201, A61K 39235, C12N 701, C12N 1586
Patent
active
060868902
ABSTRACT:
The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.
REFERENCES:
patent: 3962424 (1976-06-01), Zygraich et al.
patent: 4510245 (1985-04-01), Cousens et al.
patent: 4920209 (1990-04-01), Davis et al.
patent: 5024939 (1991-06-01), Gorman
Belak et al., "Subtypes of bovine adenovirus type 2 exhibit major differences in region E3" Virology (1986) 153:262-271.
Benko et al., "Molecular Cloning and physical mapping of the DNA of bovine adenovirus serotype 4; study of the DNA homology among bovine, and porcine adenoviruses" Journal of General Virology (1990) 71:465-469.
Berkner, K.L., "Development of Adenovirus Vectors for the Expression of Heterologous Genes" Biotechniques (1989) 6:616-629.
Bostock, C.J., "Viruses as Vectors" Vet. Microbiol. (1990) 23:55-71.
Boyle et al., "Recombinant fowlpox virus vaccines for poultry" Immunol. Cell Biol. (1993) 71:391-397.
Boyle et al., "Vectors for Recombinant Vaccine Delivery" Animal Parasite Control Utilizing Biotechnology, ed. W.K. Yong CRC Press, Boca Raton (1992) pp. 25-47.
Boyle, D.B., "How do other Poxviruses fit in as Potential Vectored Vaccine Substrates for Animal Immunizations?" Res. Virol. (1989) 140(5):483-491.
Esposito et al., "Infectious Recombinant Vectored Virus Vaccines" Adv. Vet. Sci. Comp. Med. (1989) 33:195-247.
Fejer et al., "Multiple enlargements in the right inverted terminal repeat of the DNA of canine adenovirus type 2" Acta Microbiologica Hungarica (1992) 39:159-168.
Graham et al., "Cloning and expression of glycoprotein genes in human adenovirus vectors" J. Cell. Biochem. (1988) UCLA Symposium on Molecular and Cellular Biology, Suppl. 12B, Abstract F109.
Haj-Ahmad et al., "Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene" J. Virol. (1986) 57:267-274.
Hu et al., "Sequence homology between bovine and human adenoviruses" J. Virol. (1984) 49:604-608.
Hu, S.L. et al., "Restriction Analysis and Homology Studies of the Bovine Adenovirus 7 Genome" J. Virol. (1984) 51:880-883.
Kaledin, A.S., "Cloning and Sequencing of EIA gene of bovine adenovirus 3 genome" Sbornik Nauchnykh Trudov-Moskovskaya Veterinaria Akademiya, (1988) 159:78-82 (translation provided).
Kit, S. et al., "Modified-live infectious bovine rhinotracheitis virus vaccine expressing monomer and dimer forms of foot-and-mouth disease capsid protein epitopes on surface of hybrid virus particles" Arch. Virol. (1991) 120:1-17.
Kruglyak, V.A. et al., "Cloning Fragments of Virion DNA of Cattle Adenoviruses BAV 3 In pUC 19 Plasmid" Soviet Agricultural Sciences (1987) 11:64-67.
Mittal et al., "Sequence analysis of bovine adenovirus type 3 early region 3 and fibre protein genes" J. Gen. Virol. (1992) 73:3295-3300.
Moss, B., "Recombinant DNA virus vectors for vaccination" Semin. Immunol. (1990) 2:317-327.
Prevec et al., "Use of human adenovirus-based vectors for antigen expression in animals" J. Gen. Virol. (1989) 70:429-434.
Spibey, N. et al., "Identification and nucleotide sequence of the early region 1 from canine adenovirus types 1 and 2" Virus Research (1989) 14:241-256.
Thomsen, D.R. et al., "Pseudorabies virus as a live virus vector for expression of foreign genes" Gene (1987) 5:261-265.
Tikoo, S.K. et al., "Molecular Cloning, Sequencing, and Expression of Functional Bovine Herpesvirus 1 Glycoprotein gIV in Transfected Bovine Cells" J. Virol. (1990) 64:5132-5142.
Babiuk Lorne A.
Graham Frank L.
Mittal Suresh K.
Prevec Ludvik
Mosher Mary E.
University of Saskatchewan
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