Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1992-05-26
1994-04-26
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514559, 514560, 554 1, 554220, 554222, 554224, 554223, A61K 3120
Patent
active
053067304
ABSTRACT:
A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.
REFERENCES:
patent: 4342789 (1982-08-01), Ueno et al.
Fugate et al., Applied Microbiology, vol. 21, No. 3, pp. 470-475 (1971).
Blocher et al., Food Technology, vol. 37, No. 11, pp. 87-99 (1983).
Journal of Neurochemistry, vol. 18, (1971), pp. 1751-1759, GB; L. L. Simpson et al.: "The Binding of Botulinum Toxin to membrane lipids: sphingolipids, steroids, and fatty acids".
FEBS, vol. 201, No. 2, (Jun. 1986), pp. 229-232, Federation of European Biochemical Societies; K. Takamizawa et al.: "TLC immunostaining characterization of Clostridium botulinum type A neurotoxin binding to gangliosides and free fatty acids".
Journal of Food Protection, vol. 45, No. 12, Oct. (1982), pp. 1117-1119; M. Dymicky et al.: "Inhibition of Clostridium botulinum 62A by saturated n-aliphatic acids, n-alkyl formates, acetates, propionates and butyrates".
Mutai Masahiko
Nagai Yoshitaka
Sakurai Toshizo
Takamizawa Koutaro
Takayama Hiroo
Dees Jos,e G.
Kabushiki Kaisha Yakul't Honsha
Nazario Porfirio
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