Botanical drug compositions for treatments of liver and...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...

Reexamination Certificate

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Reexamination Certificate

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07744929

ABSTRACT:
The present invention relates to compositions comprising the botanicals from the Family Ranunculaceae, Subclass: Dicotyledonae; Crassinucelli, Superorder: Ranunculales. Examples of these botanicals include but are not limited to;Actaea, Anemone, Ranunculus, andNigella, or extracts thereof, which are useful in treating liver diseases, particularly those with viral etiology. More specifically, the compositions of the present invention are derived from various botanicals or medicinal plants. The compositions of the invention have demonstrated outstanding efficacy for treatment of patients with hepatic disorders. Compositions of the present invention have also exhibited immunomodulatory activities. The preferred compositions contain the botanical ingredients in concentrations of not less than 20% w/v. The treatment can be therapeutic or prophylactic and may be administered orally, parenterally, as suppository or via nasal mucosa. The treatment may be delivered in a single dose, multi-doses or via a slow release mechanism.

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patent: 6841174 (2005-01-01), Shalaby et al.
patent: 7592327 (2009-09-01), Nassief
patent: 2002/0132019 (2002-09-01), Kandil
patent: 2002/0160065 (2002-10-01), Shalaby et al.
patent: 2004/0067263 (2004-04-01), Liu et al.
Khan, M.A.U. et al. “The In Vivo Antifungal Activity of the Aqueous Extract fromNigella sativaSeeds,” Phytotherapy Research, vol. 17, No. 2, pp. 183-186 (Feb. 2003).
Türkdo{hacek over (g)}an et al.; “The Role of Antioxidant Vitamins (C and E), Selenium andNigella sativain the Prevention of Liver Fibrosis and Cirrhosis in Rabbits: New Hopes,” Dtsch. Tierarztl. Wschr. 108, 71-73, Feb. 2001. (3 pages total).
Internet website www.botanical.com/botanical/mgmh/l/livame26.html (3 pages total) “Botanical—A Modern Herbal:Anemone hepatica” (2002).

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