Borrelia burgdorferi strain 257

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of...

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424 931, 4242341, C12N 100, C12N 120, A61K 3902

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active

054340772

ABSTRACT:
The present invention provides a vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi.
The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.

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Kramer et al Immunobiol 181:357-366 1990.
Schwan et al Journ. of Clini Microbiol. 26:893-895 1988.
Johnson et al., "Experimental Infection of the Hamster with Borrelia burgdorferi", Annals of the New York Academy of Sciences, p. 258, 1987.
Howe et al., "A Single Recombinant Plasmid Expressing Two Major Outer Surface Proteins of the Lyme Disease Spirochete", Sicence, vol. 227, p. 645 (Fe. 1985).
Barbour et al., "Heterogeneity of Major Proteins in Lyme Disease Borreliae: A Molecular Analysis of North American and European Isolates", J. Infectious Diseases, vol. 152, No. 3, p. 478, Sep. 1985.
Howe et al., "Organization of Genes Encoding Two Outer Membrane Proteins of the Lyme Disease Agent Borrelia burgdorferi within a Single Transcriptional Unit", Infection and Immunity, Oct. 1986, p. 207.
Bergstrom et al., "Molecular Analysis of linear Plasmid-encoded major surface proteins, OspA and OspB, of the Lyme Disease spirochaete Borrelia burgdorferi", Molecular Microbiology, (1989), 3(4), 479-486.
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Wallich et al., "Cloning and sequencing of the gene encoding the outer surface protein A (OspA) of a European Borrelia burgdorferi isolate", Nucleic Acids Research, Nov. 1989.
Schaible et al, Infection and Immunity, "Demonstration of Antigen-Specific T Cells and Histopathological Alterations in Mice Experimentally Inoculated with Borrelia burgdorferi", Jan. 1989, pp. 41-47.
Schaible et al., "Monoclonal Antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice", PNAS, vol. 87, pp. 3768-3772, May 1990.
Fikrig et al., "Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA", Science, Oct. 1990, p., 553.
Simon et al., "A mouse model for Borrelia burgdorfer infection: approach to a vaccine against Lyme disease", Immunology Today, vol. 12, No. 1 1991, p. 11.

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