Borrelia burgdorferi outer membrane proteins

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4242341, 435 732, 530350, A61K 3900, A61K 3902, G01N 33554, C07K 100

Patent

active

061531944

ABSTRACT:
The present invention presents three B. burgdorferi membrane proteins: Oms28, Oms45, and Oms66, each of about 28, 45, and 66 kDa respectively; and with average single channel conductances of about 0.6, 0.22, and 9.7 nS, respectively. Also disclosed are the methods for purifying these proteins from B. burgdorferi, methods for producing antibodies to these proteins, and the resulting antibodies. These proteins and their immunogenic fragments, and antibodies capable of binding to them are useful for inducing an immune response to pathogenic B. burgdorferi as well as providing a diagnostic target for Lyme disease. Further disclosed are the nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, and methods for obtaining the foregoing. Other B. burgdorferi outer membrane spanning proteins (Oms) obtainable by the isolation and purification methods of the present invention.

REFERENCES:
patent: 5470712 (1995-11-01), Simpson et al.
Skare et al. Abstract of the 96th General Meeting of the American Society for Microbiology, May 19-23, 1996. p. 248.
Skare et al. Journal of Clinical Investigation 96:2380-2392, 1995.
Skare et al. Journal of Bacteriology 178(16):4909-4918, 1996.
Norris et al. Injection and Immunity 60(11):4662-4672, 1992.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Borrelia burgdorferi outer membrane proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Borrelia burgdorferi outer membrane proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Borrelia burgdorferi outer membrane proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1722132

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.