Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1991-10-21
1999-10-12
Wax, Robert
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530825, C07K 1420
Patent
active
059657022
ABSTRACT:
This invention relates generally to an assay for Lyme disease which detects the antibody to Borrelia burgdorferi, the causative agent of Lyme disease. More specifically, the assay employs antigens derived from amino acid regions in the flagellum of Borrelia burgdorferi. These antigens are immunoreactive with antibodies to Borrelia burgdorferi but are not substantially immunoreactive with antibodies to Treponema pallidum, the syphilis causing agent. DNA sequences of the antigens, clones and vectors containing the DNA sequences are also disclosed. Polypeptides derived therefrom can be used as reagents for the detection of antibody to Borrelia burgdorferi in the body fluids from individuals with Lyme disease.
REFERENCES:
G. Gassman, et al. (1991) J. Bacteriology 173: 1452-1459.
G. Gassman, et al. (1989) Nuc. Acids Res. 17: 3590-3535.
C. Collins et al. (1991) Infect. Immun. 59: 514-520.
R. Berland, et al. (1991) Infect. Immun. 59 3531-3535.
A. Barbour, et al. 1986 Infect. Immun. 52:549-554.
E Harlow, et al. 1988 Antibodies: A Laboratory Manual. Cold Spring Harbor Press pp. 590, 567-569, 583-584.
J. Sambrook et al. 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Press pp. 17.2-17.9.
New England Nuclear Catalog 1983 pp. 139-140.
Infection and Immunity, vol. 58, No. 6, Jun. 1990, R. Wallich et al., "The Borrelia burgdorferi Flagellum-Associated 41-Kilodalton Antigen (Flagellin): Molecular Cloning, Expression, and Amplification of the Gene", pp. 1711-1719.
Hunt Jeffrey C.
Pilot-Matias Tami J.
Robinson John M.
Abbott Laboratories
Becker Cheryl L.
Bugaisky Gabriele E.
Wax Robert
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