Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-07-10
1997-07-01
Housel, James C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 693, 435 697, 4351723, 4353201, 935 22, 935 38, C12P 2106, C12N 1500, C12N 1509, C12N 1563
Patent
active
056437510
ABSTRACT:
This invention relates generally to an assay for Lyme disease which detects the antibody to Borrelia burgdorferi, the causative agent of Lyme disease. More specifically, the assay employs antigens derived from amino acid regions in the flagellum of Borrelia burgdorferi. These antigens are immunoreactive with antibodies to Borrelia burgdorferi but are not substantially immunoreactive with antibodies to Treponema pallidum, the syphilis causing agent. DNA sequences of the antigens, clones and vectors containing the DNA sequences are also disclosed. Polypeptides derived therefrom can be used as reagents for the detection of antibody to Borrelia burgdorferi in the body fluids from individuals with Lyme disease.
REFERENCES:
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Infection and Immunity, vol. 52, No. 5, May 1986, A.G. Barbour et al., "A Borrelia-Specific Monoclonal Antibody Binds to a Flagellar Epitope", pp. 549-554.
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Infection and Immunity, vol. 58, No. 6, Jun. 1990, R. Wallich et al., "The Borrelia burgdorferi Flagellum-Associated 41-Kilodalton Antigen (Flagellin): Molecular Cloning, Expression, and Amplification of the Gene", pp. 1711-1719.
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Hunt Jeffrey C.
Pilot-Matias Tami J.
Robinson John M.
Abbott Laboratories
Becker Cheryl L.
Housel James C.
Swartz Rodney P.
Weinstein David L.
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