Borrelia burdorferi Osp A and B proteins and immunogenic peptide

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lipoproteins – e.g. – egg yolk proteins – cylomicrons – etc.

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530350, 530806, 4241851, 4241901, 4241931, 42419711, 4242011, 4242021, 4242031, 514 2, C07K 100, C07K 1600, A61K 3900, A61K 3902

Patent

active

061438723

ABSTRACT:
Disclosed and claimed are isolated polypeptides consisting of amino acid sequences derived form ospA and/or ospB of various B. burgdorferi or portions thereof and methods of making and using the same.

REFERENCES:
patent: 4888276 (1989-12-01), Shelbourne
patent: 5178859 (1993-01-01), Simon et al.
patent: 5523089 (1996-06-01), Bergstrom et al.
patent: 5582990 (1996-12-01), Bergstrom et al.
patent: 5688512 (1997-11-01), Bergstrom et al.
Calderwood et al, "Iron regulation of shiga like toxin expression in Escherichia coli is mediated by the fur locus", J. Bacteriol. 169(10):4759-4764, Oct. 1987.
Vlasuk et al, "Effects of the complete removal of basic amino acid residues from the signal peptide on secretion of lipoprotein in Escherichia coli", J. Biol. Chem. 258(11):7141-7148, Jun. 1983.
Jonsson et al, "Heterogeneity of outer membrane proteins in Borrelia burgdorferi: comparison of Osp operons of three isolates of different geographic origins", Inf. Immun. 60(5):1845-1853, May 1992.
Bockenstedt et al, "Inability of truncated recombinant Osp A proteins to elicit protective immunity to Borrelia burgdorferi in mice", J. Immunol. 151:900-906, Jul. 1993.
Guy et al., "Detection of Borrelia burgdorferi in patients with Lyme diseae by the polymerase chain reaction.", J Clin Pathol. 1991 Jul.; 44(7): 610-611.
Gyllensten, U. in "PCR technology--principles and application for DNA amplification". pp. 45-60, 1989.
Nucleotide sequence search printout (EMBL, GenBank, N-GeneSeq.) (Nov. 9, 1992).
Fellinger et al., "Sequence of the complete osp operon encoding two major outer membrane proteins of European Borrelia burgdorferi isolate (B29)",Gene, 120, 127-128, 1992.
Rosa et al., "Molecular analysis of the major outer surface protein locus from a divergent Borrelia burgdorferi isolate from Europe", Curr. Communications in Cell and Mol. Biol. 5 (Schutzer ed.) Cold Spring Harbor Press, Cold Spring Habor, New York, Date Not Available.
Zumstein et al., "Genetic polymorphism of the gene encoding the outer surface protein A (OspA) of Borrelia burgdorferi", Med. Microbiol. Immunol., 181, 57-70, 1992.
Asbrink, E. & A Hovmark. 1985. Successful cultivation of spirochetes from skin lesions of patients with erythema chronicum mirgran Afzelius and acrodermatitis chronica atrophican. Acta. Path. Microbiol. Immunol. Scand. Sect. B, 93: 161-163.
Barbour et al., The Yale Journal of Biology and Med. 57: 581-586, 1984.
Barbour, A.G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Bil. Med. 57: 71-75.
Barbour, A.G. 1984. Immunochemical analyis of Lyme disease spirochetes. Yale J. Biol. Med. 57: 581-586.
Barbour, A.G. 1988. Plasmid Analysis of Borrelia burgdorferi, the Lyme Disease Agent. Journal of Clinical Microbiology 26: 475-478.
Barbour, A.G. 1989. Antigenic variation in relapsing fever Borrelia species: genetic aspects. In Berg, D.E. & Howe, M.M. (eds): Mobile DNA, Washington, D.C. American Society for Microbiology, pp. 783-789.
Barbour, A.G. & C.F. Garon. 1987. Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science 237: 409-411.
Barbour, A.G., R.A. Heiland & T.R. Howe. 1985. Heterogeneity of major proteins in Lyme disease borreliae: a molecular analysis of North American and European isolates. J. Infect. Dis. 153: 478-484.
Barbour, A.G. & M.E. Schrumpf. 1986. Polymorphism of major surface proteins of Borrelia burgdorferi. Zentralbl. Bakteriol. Parasitenkd. Infektionskr. Hyg. Abt. 1 Orig. Reihe A. 263: 83-91.
Barbour, A.G., S.L. Tessier & S.F. Hayes. 1984. Variation in a major surface protein of Lyme disease spirochetes. Infect. Immun. 45: 94-100.
Barbour, A.G., Sl.L. Tessier & W.J. Todd. 1983. Lyme disease spirochetes and Ixodes ticks share a common surface antigenic determinant defined by a monoclonal antibody. Infect. Immun. 41: 795-804.
Barbour, A.G., N. Burman, C.J. Carter, T. Kitten & S. Bergstrom. 1991. Variable antigen genes of the relapsing fever agent Borrelia hermsii are activated by promoter addition. Mol. Microbiol. 5: 489-493.
Barbour, A.G., C.J. Carter, N. Burman, C.S. Freitag, C.F. Garon & S. Bergstrom. 1991. Tandem insertion sequence-like elements define the expression site for variable antigen genes of Borrelia hermsii. Infect. Immun. 59: 390-397.
Barstad et al Journal of Exp. Med. 161:1302-1314, 1986.
Bergstrom, S., K. Robbins, M. Koomey & J. Swanson. 1986. Piliation control mechanism in Neisseria gonorrhoeae. Proc. Natl. Acad. Sci. USA 83: 479-486.
Bergstrom, S., V.G. Bundoc & A.G. Barbour. 1989. Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochete Borrelia burgdorferi. Mol. Microbiol. 3: 479-486.
Brandt, M.E., B.S. Riley, J.D. Radolf & M.V Norgard. 1990. Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins. Infect. Immun. 58: 983-991.
Bundoc, V.G. & A.G. Barbour. 1989. Clonal polymorphism of outer membrane protein OspB of Borrelia burgdorferi. Infect. Immun. 57: 2733-2741.
Burman, N., S. Bergstrom, B.I. Restrepo & A.G. Barbour. 1990. The variable antigens Vmp7 and Vmp21 of the relapsing fever bacterium Borrelia hermsii are structurally analogous to the VSG proteins of the African trypanosome. Mol. Microbiol. 4: 1715-1726.
Coleman et al. Journal of Infect. Dis. 155: 756-765, 1987.
Coleman et al. Zbl. Bakt. Hyg. A 263: 123-126, 1986.
Craft, J.E., D.K. Fischer, G.T. Shimamoto & A.C. Steere. 1986. Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new IgM response and expansion of the IgG response late in illness. J. Clin. Invest. 78: 934-939.
Cunningham et al., Annals of the New York Academy of Sciences 539: 371-378, 1988.
Fikrig, E., S.W. Barthold, F.S. Kantor & R.A Flavell. 1990. Protection of mice against the Lyme Disease agent by immunizing with recombinant OspA. Science 250: 553-556.
Fikrig et al., Impact & Immunity 60: 773-777. 1992.
Harr, R., P. Fallman, M. Haggstrom, L. Wahlstrom & P. Gustafsson. 1986. Geneus, a computer system for DNA and protein sequence analysis containing an information retrieval system for the EMBL data library. Nucl. Acids. Res. 11: 273-284.
Hoheisel, J. & F.M. Pohl. 1986. Simplified preparation of unidirectional deletion clones. Nucl. Acids Res. 14. 3605.
Howe, T.R., F.W. LeQuier & A.G. Barbour. 1986. Organization of genes encoding two outer membrane proteins of the Lyme disease agent with a single transcriptional unit. Infect. Immun. 54. 207-212.
Howe, T.R., L.W. Mayer & A.G. Barbour. 1985. A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirochete. Science 227: 645-646.
Huynh, T.U., R.A. Young & R.W. Davis. 1985. Construction and screening cDNA libraries in Agt10 and Agt11. In DNA Cloning, vol. 1, ed. Glover, D.M. IRL Press Limited, Oxford, England, pp. 56-110.
Inouye, M. & S. Halegoua. 1980. Secretion and membrane localization of proteins in Escherichia coli. Crit. Rev. Biochem. 7: 339-371.
Jameson, B.A. & H. Wolf. 1988. The antigenic index: a novel algorithm for predicting antigenic determinants. Comput. Appl. Biosci. 4: 181-186.
Kyruchechnikov, V.N., E. I. Korenberg, S.V. Scherbakov, Yu.V. Yovalevsky & M.L. Levin. 1988. Identification of Borrelia isolated in the USSR form Ixodes persulcatus schulze ticks. J. Microbiol. Epidemiol. Immunobiol. 12: 41-44.
Loenen, W.A.M. & W.J. Brammer. 1980. A bacteriophage lambda vector for cloning large DNA fragments made with several restriction enzymes. Gene 20: 249-259.
Luft et al., Annals of the New York Academy of Sciences 559: 398-399. Date Not Available.
Malloy, D.C. , R.K. Nauman & H. Paxton. 1990. Detection of Borrelia burgdorferi using the polymerase chain reaction. J. Clin. Microbiol. 28: 1089-1093.
Maniatis, T.E., E.F. Fritsch & J. Sambrook. 1982. Molecular cloning: A laboratory manual. Cold Spring Harbor, New York, Cold Spring Harbor, N.Y. USA Laboratory Press.
Marx et al., Annals of the New York Acad. of Sciences 539:398-399, 1988.
Meier, J.T., M.I. Simon & A.G. Barbour. 1985. Antigenic variation is associated with DNA rearrangements in a relapsing fever borrelia. Cell 41: 403-409.
Nielsen, S.L.,

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Borrelia burdorferi Osp A and B proteins and immunogenic peptide does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Borrelia burdorferi Osp A and B proteins and immunogenic peptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Borrelia burdorferi Osp A and B proteins and immunogenic peptide will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1642456

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.