Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-06
2000-07-04
Housel, James C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 912, 435 6, 536 234, 536 237, C12P 2106, C12P 1934, C07H 2104
Patent
active
060837225
ABSTRACT:
Disclosed and claimed are Lyme disease vaccines and methods for making and using them. The vaccines include a vector containing DNA encoding OspA or an immunogenic fragment thereof or such DNA encoding OspA or an immunogenic fragment thereof which has been modified by substitution, addition, insertion or deletion of one or more nucleotides, whereby the DNA when expressed results in OspA, or an immunogenic fragment thereof, or a polypeptide having the immunological activity of OspA or the fragment thereof.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4721617 (1988-01-01), Johnson
patent: 4888276 (1989-12-01), Shelbourne
patent: 4981685 (1991-01-01), Healey
patent: 5582990 (1996-12-01), Bergstrom et al.
Hansen et al., "Measurement of antibodies to the Borrelia burgdorferi flagellum improves serodiagnosis in Lyme disease", J. Clin. Microbiol. 26 (Feb. 1988), 338-346.
Howe et al, "Organization of genes encoding two outer membrane proteins of the lyme disease agent Borrelia burgdorferi within a single transriptional unit", Infection and Immunity, 54(1):207-212.
Howe T.R., et al., Science 227 (1985), 645-646.
Lastavica et al., Pbl. Bakt. Hyg. A 263 (1986), 288.
Luft et al., "Biochemical and immunological Characterization of the surface proteins of Borrelia burgdorferi", Infection and Immunity, vol. 57, No. 11, 1989.
Magnarelli et al., "EnPyme-linked immunoabsorbent assays for the detection of class-specific immunoglobulins to Borrelia burgdorferi", Am. J. Epidemiology 127 (4) (1988), 818-825.
Maniatis et al., Molecular Cloning-- A Laboratory Manual, Cold Spring Harbor Laboratory, 1982.
Ugle et al., J. Mol. Biol., 1982, 157:105-132.
Voller et al., The En(x)yme Linked Immunosorbent Assay (ELISA), 1979, Dynatech Europe, Borough House, Guernsey.
Vunakis, Helen Van et al.: "Enzyme Immunoassay ELISA and EMIT", Methods in Enzymology, vol. 70 (1980).
Wilskie et al., Res. Microbiol., 143, 1992, 583-596.
Wokke et al., Neurology 37 (1987), 1031-1034, 1987.
Aberer E., et al., "Molecular and Lyme Borreliosis: A Shared Antigenic Determinant between Borrelia Burgdorferi and Human Peripheral Nervous System", pp. 1-16 (1988).
Anderson et al., "Prevalence of Borrelia burgdorferi in White-Footed Mice and Ixodes dammini at Fort McCoy, Wis.", J. Clin. Microbiol. 25(8) (1987), 1495-1497.
Bergstrom, S. et al., Molec. Microbiology, (1989), 479-486.
Coleman, J.L. et al., "Isolation of the outer envelope from Borrelia Burgdorferi", Pentralbl Bakteriol Mikrobiol Hyg aaa Dec. 1986, 263 (1-2), 123-126.
Cunningham et al., "Identification of Borrelia burgdorferi Surface Components by Triton X-114 Phase Partioning", Ann N.Y. Acad. Sci 539 (1988), 376-378.
Dattwyler et al., "Specific Immune Responses in Lyme Borreliosis", Ann. NY Acad. Science 539 (1988), 93-106.
Fikrig et al., (Infect. and Immun.) 60, 773-777, 1992.
Asbrink et al., "The Spirochetal Etiology of Acrodermatitis chronica atrophicans Herxheimer", Acta Derm Venersol (Stockh), 64:506-512 (1984).
Barbour et al., Antibodies of patients with Lyme disease to components of the Ixodes damini spriochette, Journal of Clinical Investigation, 72:504-514 (Aug. 1983).
Barbour et al., "Lyme Disease Spirochetes and Ixodid Tick Spirochetes Share a Common Antigenic Determinant Defined by a Monoclonal Antibody", Infect. Immun., 1983, 41: 795-804.
Barbour et al., "Heterogeneity of Major Proteins in Lyme Disease Borreliae: A Molecular Analysis of North American and European Isolates", The Journal of Infectious Diseases, 57:581-586 (1984).
Barbour et al., "Heterogeneity of Major Proteins in Lyme Disease Borreliae: A Molecular Analysis of North American and Europena Isolates", J. Infect. Dis., 1985, 152: 478-484.
Barbour et al., "Biology of Borrelia Species", Macrobiological Reviews, 50(4):381-400 (1986).
Barbour et al., "A Borrelia-Specific Monoclonal Antibody Binds to a Flagellar Epitope", Infection and Immunity, 52(5):549-554 (1986).
Barstad et al., "Variable Major Proteins of Borrelia Hermsil", J. Exp. Med., 161:1302-1314 (1985).
Barstad et al., Journal of Exp. Med. 161: 1302-1314. 1986 Marx et al., Annals of the New York Acad. of Sciences, 539: 398-399, 1988.
Bertani, G. "Studies on Lysogenesis", J. Bacteriol., 62:293-3000 (1952).
Brown, F., "Synthesis peptides as potential vaccines against foot-and-mouth disease", Endeavor, New Series, 14(2):87 (1990).
Burnham, T.K., and Bank, P.W.: Antinuclear antibodies. I. Pattern of nuclear immunofluorescence. J. Invest. Dermatol., 1974, 62: 526-534.
Chou et al., "Prediction of beta-Turns", Biophysical Journal, 26:367-384 (1979).
Coleman et al., The J of Inf Dis, vol. 155, Apr. 1987, pp. 756-765, "Isolation of Antigenic Components from the Lyme Disease Spirochete: Their Role in Early Diagnosis".
Craft et al., J. Infect. Dis., 1984, 149: 789-795 "Antibody Responses in Lyme Disease: Evaluation of Diagnostic Tests".
Craft et al., J. Clinical Immunity., 1986, vol. 78, pp. 934-939, Antigens of Borrelia burgdorferi Recognized during Lyme Disease.
Dalchau et al., "Monoclonal antibody to a human leukocyte-specific membrane glycoprotein probably homologous to the leukocyte-common (L-C) antigen of the rat", Eur. J. Immunol., 10:737-744 (1980).
Dayhoff et al., "Establishing Homologies in Protein Sequences", Methods in Enzymology, 91:524-545 (1983).
Fikrig et al., "Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA", Science, 25:553-556 (1990).
Garnier et al., "Analysis of the Accuracy and Implications of Simple Methods for Predicting the Secondary Structure of Globular Proteins", J. Med. Biol., 120:97-120 (1978).
Gill et al., "A new cell division operon in Escherichia coli", Mol. Gen Gent, 205:134-145 (1986).
Gold et al., "Translation Initiation in Prokaryotes", Ann. Rev. Microbiol., 35:365-403 (1981).
Grodzicki et al., "Comparison of Immunoblotting and Indirect Enzyme-Linked Immunosorbent Assay Using Different Antigen Preparations for Diagnosing Early Lyme Disease", The Journal of Infectious Diseases, 157(4):790-797 (1988).
Hanahan, D. "Studies on Transformation of Escherichia coli with Plasmids", J. Mol. Biol., 166:557-580 (1983).
Hansen et al., Immunochemical characterization of and isolation of the gene for a Borrelia Burdorferi immunodominant 60-K antigen common to a wide range of bacteria, Infection & Immunity, 56:2047-2053 (1988).
Harlow et al., Antibodies A Laboratory Manual, Coldspring Harbor, 1988, pp. 591-592.
Harr et al., "GENEUS, a computer system for DNA and protein sequence analysis containing an information retrieval system for the EMBL data library", Nucleic Acid Research, 14(1):273-284 (1985).
Hopp et al., "Predicition of protein antigen determinants from amino acid sequences", Proc. Natl. Acad. Sci. USA, 78(6):3824-3828 (1981).
Hotez et al, "Hookworm Antigens: the Potential for Vaccination", Parasitology Today, 3(8):247-249 (1987).
Howe et al., (2) Inf I'mm, vol. 54, p. 207, Oct. 1986, Organization of Genes Encoding Two Outer Membranes.
Hyde et al., "Genetic Relationship of Lyme Disease Spirochetes to Borrelia, Treponema, and Leptospira spp.", Journal of Clinical Microbiology, 20(2):151-154 (1984).
Kyte et al., "A Simple Method for Displaying the Hydropathic Character of a Protein", J. Mol. Biol., 157:105-132 (1982).
Lipman et al., "Rapid and Sensitive Protein Similarity Searches", Science, 227 1435-1441 (1985).
Magnarelli et al., "Cross-Reactivity in Serological Tests for Lyme Diseasee and Other Spirochetal Infections", J. Infect. Dis., 1987, 156: 183-188.
Magnarelli et al., "Comparison of an Indirect Fluorescent-Antibody Test with an Enzyme-Linked Immunosorbent Assay for Serological Studies of Lyme Disease", Journal of Clinical Microbiology, 20(2):181-184 (1984).
Matthes et al., "Simultaneous rapid chemical synthesis of over one hundred oligonucleotides on a microscale", The EMBO Journal, 3:801-805 (1984).
McLaughlin et al., "Unique Features in the Ribosome Binding Site Sequence of the Gram-positive Staphylococcus aureaus beta-Lactamase Gene", The Journal of Biological Chemistry, 256(21):11283-11291 (1981).
Merrifield, R.B., "Solid Phase Peptide Synthesis. I. The Synt
Barbour Alan G.
Bergstrom Sven
Magnarelli Louis A.
Frommer William S.
Housel James C.
Kowalski Thomas J.
Swartz Rodney P.
Symbicom AB
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