Borrelia antigen

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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4242341, 435 72, A61K 3900, A61K 3902

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active

055230890

ABSTRACT:
B fraction of Borrelia burgdorferi, methods for preparing the B fraction, and compositions containing the B fraction, are disclosed and claimed.

REFERENCES:
patent: 4888276 (1989-12-01), Shelbourne
patent: 4981685 (1991-11-01), Healey
Wilske et al Research Microbiol 143:583-596, 1992.
Fikrig et al Infect & Immunity 60:773-777, 1992.
Cunningham et al Annals of The New York Academy of Sciences 539:376-378, 1988.
Barbour et al The Yale Journ of Biology & Med 57:581-586, 1984.
Coleman et al Journ of Infect Dis. 155:756-765 1987.
Barstad et al Journal of Exp. Med 161:1302-1314 1986.
Marx et al Annals of the New York Acad of Sciences 539:398-399, 1988.
Luft et al Annals of The New York Academy of Sciences 539:398-399.
Coleman et al 261 Bakt, Hyg A 263:123-126 1986.
Helenius et al, Biochimica et Biophysica Acta 415:29-79, 1975 Solubilization of Membranes by Detergents.
Pohl, Guide to Protein Purification vol. 182 Chapter 7, 68-69, 1990.
Phillips et al, Infect & Immunology 61:3047-3059, 1993.
Neugebauer in Guide to Protein Purification vol. 182 Chapter 18, pp. 239-253, 1990.
Hjelmeland in Guide to Protein Purification vol. 182, Chapter 19 pp. 253-264, 1990.
Barbour et al, Microbiological Rev. 50:381-400 1986.
Sparling et al in Microbiology, 3rd Edition, 1980 Chapter 39, The Spirochetes pp. 752-762.
Fikrig et al, "Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA", Science, 25:553-556 (1990).
Schaible et al, "Monoclonal antiobodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice", Proc. Natl. Acad. Sci. USA, 87:3768-3772 (1990).
Milch & Barbour, "Analysis of North American and European Isolates of Borrelia burgdorferi with Antiserum to a Recombianant Antigen", The Journal of Infectious Diseases, 160(2):351-353 (1989).
Aberer et al, "Molecular Mimicry and Lyme Borreliosis: A Shared Antigenic Determinent between Borrelia Burgdorferiand Human Peripheral Nervous System", pp. 1-16 (1988).
Szmuness et al, "Hepatitis B Vaccine: Demonstration of Efficacy in a Controlled Clinical Trial in a High-Risk Population in the United States", The New England Journal of Medicine, 303(15):833-841 (1980).
Brown, F., "Synthetic peptides as potential vaccines against foot-and-mouth disease", Endeavour, New Series, 14(2), p 87 (1990).
Hotez et al, "Hookworm Antigens: the Potential for Vaccination", Parasitology Today, 3(8):247-249 (1987).
Steere et al, "The Spirochetal Etiology of Lyme Disease", The New England Journal of Medicine, 308(13):733-740 (1983).
Asbrink et al, "The Spirochetal Etiology of Acrodermatitis chronica atrophicans Herxheimer", Acta Derm Venereol (Stockh), 64:506-512 (1984).
Barbour et al, "Biology of Borrelia Species", Macrobiological Reviews, 50(4):381-400 (1986).
Pfister et al, "The spirochetal etiology of lymphocytic meningoradiculitis of Bannwarth (Bannwarth's syndrome)", J. Neurol., 231:141-144 (1984).
Steere et al, "Lyme Carditis: Cardiac Abnormalities of Lyme Disease", Annals of Internal Medicine, 83(1):8-16 (1980).
Steere et al, "Chronic Lyme Arthritis: Clinical and Immunogenetic Differentiation from Rheumatoid Arthritis", Annals of Internal Medicine, 90:896-901 (1979).
Steere et al, "The Early Clinical Manifestations of Lyme Disease", Annals of Internal Medicine, 99:76-82 (1983).
Magnarelli et al, "Comparison of an Indirect Fluoroescent-Antibody Test with an Enzyme-Linked Immunosorbent Assay for Serological Studies of Lyme Disease", Journal of Clinical Microbiology, 20(2):181-184 (1984).
Craft et al, "Antibody Response in Lyme Disease: Evaluation of Diagnostic Tests", The Journal of Infectious Diseases, 149(5):789-795 (1984).
Barbour et al, "Lyme Disease Spirochetes and Ixodid Tick Spirochetes Share a Common Surface Antigenic Determinant Defined by a Monoclonal Antibody", Infection and Immunity, 41(2):795-804 (1983).
Magnarelli et al, "Cross-Reactivity in Serological Tests for Lyme Disease and Other Spirochetal Infections", The Journal of Infectious Diseases, 156(1):183-188 (1987).
Voller et al, "Enzyme-Linked Immunosorbent Assay", Manual of Clinical Immunology, 2nd ed., 1980, pp. 359-371.
Asbrink et al, "Serologic Studies of Erythema chronicum migrans Afzelius and Acrodermatitis chronica atrophicans with Indirect Immunofluorescence and Enzyme-Linked Immunosorbent Assays", Acta Derm Venereol (Stockh), 65:509-514 (1985).
Saiki et al, "Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polyermase", Science, 239:487-491 (1988).
Kyte et al, "A Simple Method for Displaying the Hydropathic Character of a Protein", J. Mol. Biol., 157:105-132 (1982).
Saiki et al, "Enzymatic Amplification of Beta-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia", Science, 230:1350-1354 (1985).
Barbour et al, "A Borrelia-Specific Monoclonal Antibody Binds to a Flagellar Epitope", Infection and Immunity, 52(5):549-554 (1986).
von Heijne, G. "Patterns of Amino Acids near Signal-Sequence Cleavage Sites", Eur. J. Biochem., 133:17-21 (1983).
Barstad et al, "Variable Major Proteins of Borrelia hermsii", Journal of Experimental Medicine, 161:1302-1314 (1985).
Barbour et al, "Heterogeneity of Major Proteins in Lyme Disease Borreliae: A Molecular Analysis of North American and European Isolates", The Journal of Infectious Diseases, 152(3):478-484 (1985).
Barbour et al, "Immunochemical Analysis of Lyme Disease Spirochetes", The Yale Journal of Biology and Medicine, 57:581-586 (1984).
Gold et al, "Translational Initiation in Prokaryotes", Ann. Rev. Microbiol., 35:365-403 (1981).
Rosenberg et al, "Regulatory Sequences Involved in the Promotion and Termination of RNA Transcription", Ann. Rev. Genet., 13:319-353 (1979).
Matthes et al, "Simultaneous rapid chemical synthesis of over one hundred oligonucleotides on a microscale", The EMBO Journal, 3:801-805 (1984).
Merrified, R. B., "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide", J. Am. Chem. Soc., 85:2149-2154 (1963).
Shinnick et al, "Synthetic Peptide Immunogens as Vaccines", Ann. Rev. Microbiol., 37-425-446 (1983).
Dalchau et al, "Monoclonal antibody to a human leukocyte-specific membrane glycoprotein probably homologous to the leukocyte-common (L-C) antigen of the rat", Eur. J. Immunol., 10:737-744 (1980).
Hopp et al, "Prediction of protein antigenic determinants from amino acid sequences", Proc. Natl. Acas. Sci. USA, 78(6):3824-3828 (1981).
Garnier et al, "Analysis of the Accuracy and Implications of Simple Methods for Predicting the Secondary Structure of Globular Proteins", J. Med. Biol., 120:97-120 (1978).
Chou et al, "Prediction of beta-Turns", Biophysical Journal, 26:367-384 (1979).
Harr et al, "GENEUS, a computer system for DNA and protein sequence analysis containing an information retrieval system for the EMBL data library", Nucleic Acid Research, 14(1):273-284 (1985).
Bergstroem et al, "Molecular analysis of linear plasmid encoded major surface proteins, OspA and OspB, of the Lyme disease spirochete Borrelia burgdorferi", pp. 1-28, submitted for publication.
Vogel et al, "Acetylornithinase of Escherichia coli: Partial Purification and some Properties", J. Biol. Chem., 218:97-106 (1956).
Hanahan, D. "Studies on Transformation of Escherichia coli with Plasmids", J. Mol. Biol., 166:557-580 (1983).
Sanger et al, "DNA sequencing with chain-terminating inhibitors", Proc. Natl. Acad. Sci. USA, 74(12):5463-5467 (1977).
Gill et al, "A new cell division operon in Escherichia coli", Mol Gen Genet, 205:134-145 (1986).
Messing et al, "A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments", Gene, 19:269-276 (1982).
Bertani, G. "Studies on Lysogenesis", J. Bacteriol., 62:293-300 (1952).
Dayhoff et al, "Establishing Homologies in Protein Sequences", Methods in Enzymology, 91:524-545 (1983).
Hyde et al, "Genetic Relationship of Lyme Disease Spirochetes to Borrelia, Treponema, and Leptospira spp.", Journal of Clinical Microbiology, 20(2):151-154 (1984).
McLaughlin et al, "Unique Features in the Ribosome Binding Site Sequen

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