Boronophenyl analogs of phospholyrosines

Details Boronophenyl analogs of phospholyrosines Boronophenyl analogs of phospholyrosines

1995-05-31

1998-07-07

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530330, 530331, 556 7, 564152, 564153, A61K 3805, A61K 3807, C07K 506, C07K 508

Patent

active

057769028

ABSTRACT:
The present invention makes available novel compounds useful for inhibiting kinases, phosphatases and SH2 domains, e.g., an interaction between a protein containing an SH2 domain and a phophotyrosine-containing polypeptide. In one embodiment, the present invention provides boronylphenyl analogs of phosphotyrosines which, in such forms as peptidomimetics, can be used to modulate signal transduction pathways in cells.

REFERENCES:
CA 125: 143313, 1996.
CA 115: 109152, 1991
CA 122: 234072, 1994.

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