Boronic compound complexing reagents and complexes

Details Boronic compound complexing reagents and complexes Boronic compound complexing reagents and complexes

1997-10-22

1999-02-09

Raymond, Richard L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

424450, 530345, 530350, 5303971, 530402, 536 171, 546291, 546292, 5483381, 548542, 548547, 558 6, 558399, 560 18, 560 34, 560 42, C07C25910

Patent

active

058696237

ABSTRACT:
Boron compound complexing reagents, intermediate reagents of those reagents, and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula II may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain of up to about 6 carbon equivalents in length, an unbranched saturated or unsaturated chain from about 6 to 18 carbon equivalents in length with at least one intermediate amide or disulfide moieties, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; group R.sub.2 is one of an alkyl and a methylene group with an electronegative moiety; and BAS is a biologically active species.

REFERENCES:
patent: 5594151 (1997-01-01), Stolowitz

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