Boronic acid-contaning nucleic acid monomers

Details Boronic acid-contaning nucleic acid monomers Boronic acid-contaning nucleic acid monomers

1996-08-05

1998-11-03

Marschel, Ardin H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 243, 536 253, 435 6, 546 1, 546 20, 548517, 548518, C12Q 168, C07H 1900, C07D21300, C07C 5110

Patent

active

058310460

ABSTRACT:
Modified nucleotides and polynucleotides which are useful in hybridization assays for the detection of target genes are provided. The modified polynucleotides contain at least one boronic acid moiety which is attached to a nucleotide base in a position which does not interfere with the hydrogen bonding capabilities of that base during duplex formation. The modified polynucleotides are typically formed from naturally occurring nucleotides and one or more modified nucleotides.

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