Boronic acid and ester inhibitors of thrombin

Details Boronic acid and ester inhibitors of thrombin Boronic acid and ester inhibitors of thrombin

1996-07-26

1997-12-16

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

558286, 558287, 558288, 558289, 558298, 562 7, 562806, 564 8, 564 9, 564 10, 568 1, 568 6, A61K 3169, C07D 504

Patent

active

056985380

ABSTRACT:
Novel boronic acid and ester and carboxyl-modified amino acid compounds of the Formula I, which are inhibitors of trypsin-like enzymes, are disclosed :

REFERENCES:
patent: 4963655 (1990-10-01), Kinder et al.
CA87:163396u Amino methaneboronic acids. Synthesis . . . substrates. Lindquist et al., p. 195, 1977.
CA101:225600z Benzamidomethane boronic acid: . . . chymotrypsin. Amiri et al., p. 341, 1984.
CA108:218119r .beta.-lactamase . . . boronic acids. Crompton et al., p. 243, 1988.
CA 121:136648s Liquid . . . enzyme stability.Labeque et al., p. 140, 1994.

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