Boronic acid adducts of rhenium dioxime and technetium-99m dioxi

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to cyclopentano-hydrophenanthrene ; derivative thereof

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 165, 424 169, 424 173, 534 10, 534 14, A61K 4902, A61K 4300

Patent

active

053874099

ABSTRACT:
Boronic acid adducts of technetium-99m and radioactive rhenium dioxime complexes, each of which include biochemically active groups, are useful as diagnostic and therapeutic agents, respectively.

REFERENCES:
patent: 4431627 (1984-02-01), Eckelman et al.
patent: 4705849 (1987-11-01), Nunn et al.
patent: 4871836 (1989-10-01), Francesconi et al.
Chemical Abstracts, Abstract No. 59625V, vol. 84, p. 545, 1976.
Chemical Abstracts, Abstract No. 11735q, vol. 70, p. 293, 1969.
Fowler et al., Int. J. Appl. Radiat. Isot., 1986, 27, pp. 663-668, "2-deoxy-2[.sup.18 F]fluoro-D-glucose for metabolic studies: current status".
Winchell et al., J. Nucl. Med., 1980, 21, pp. 940-946 "Development of I-123-Labeled Amines for Brain Studies: Localization of I-123 Iodophenylalkyl Amines in Rat Brain".
Winchell et al., J. Nucl. Med., 1980, 21, pp. 947-952, "N-Isopropyl-[.sup.123 I]p-Iodoamphetamine: Single-Pass Brain Uptake and Washout; Binding to Brain Synaptosomes and Localization in Dog and Monkey Brain".
van der Wall et al., Eur. J. Nucl. Med., 1986, 12, pp. 511-515, "Myocardial Imaging with Radiolabeled Free Fatty Acids: Applications and Limitations".
Jones et al., J. Nucl. Med., 1988, 29(5), p. 935 "Synthesis of a Novel [Tc99m]-Diaminodithiol-Fatty Acid (TcN.sub.2 S.sub.2 FA) Complex and its Evaluation as a Myocardial Imaging Agent".
Jagoda et al., J. Nucl. Med., 1984, 25, pp. 472-477, "[.sup.125 I]-17-Iodovinyl-11-Methoxyestradiol: In vivo and In vitro Properties of a High Affinity Estrogen-Receptor Radiopharmaceutical".
Gibson et al., Biochem. Pharm., vol. 32, No. 12, pp. 1851-1856, 1983, "Differences in Affinities for Muscarinic Acetylcholine Receptor Antagonists for Brain and Heart Receptors".
Gibson et al., J. Nucl. Med., vol. 25, No. 2, pp. 214-222, 1984, "The Characteristics of I-125 4-IQNB and H-3QNB In Vivo and In Vitro".
Martin et al., J. Nucl. Med., vol. 30, No. 2, 194-201 (1989) "Enhanced Binding of the Hypoxic Cell Marker [.sup.3 H] Fluoromisonidazole".
Hoffman et al., Stroke, 18, p. 168 (1987) "Binding of the Hypoxic Tracer [H-3] Misonidazole in Cerebral Ischemia".
Koh et al., J. Nucl. Med., p. 789, 30, 1989 "Hypoxia Imaging of Tumors Using [F-18] Fluoromisonidazole".
Kedderis et al., Drug Metabolism Reviews, 19(1), pp. 33-62 (1988) "The Metabolic Activation of Nitro-Heterocyclic Therapeutic Agents".
Adams, et al., Biochem. Pharmacology, vol. 35, No. 1, pp. 71-76 (1986) "Hypoxia Mediated Nitro-Heterocyclic Drugs in the Radio- and Chemotherapy of Cancer".
Brown et al., Rad. Research, 90, pp. 98-108 (1982) "Structure-Activity Relationships of 1-Substituted 2-Nitroimidazoles: Effect of Partition Coefficient and Sidechain Hydroxyl Groups on Radiosensitization in vitro".
Adams et al., Int. J. Radiat. Biol., vol. 35, No. 2, pp. 133-150 (1979) "Structure-Activity Relationships in the Development of Hypoxic Cell Radiosensitizers".
Adams et al., Int. J. Radiat. Biol., vol. 38, No. 6, 613-626 (1980) "Structure-Activity Relationships in the Development of Hypoxic Cell Radiosensitizers".
Kabalka et al., Nucl. Med. Biol., 1989, 16(4), pp. 359-360.
Y. Lixi et al., Journal of Medical Colleges of PLA, 2(3): pp. 265-269, 1987, "Synthesis of Metronidazole Derivative and its Distribution in Sarcoma 180 Bearing Mice".

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Boronic acid adducts of rhenium dioxime and technetium-99m dioxi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Boronic acid adducts of rhenium dioxime and technetium-99m dioxi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Boronic acid adducts of rhenium dioxime and technetium-99m dioxi will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1109021

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.