Boronic acid adducts of metal dioxime complexes useful in labell

Details Boronic acid adducts of metal dioxime complexes useful in labell Boronic acid adducts of metal dioxime complexes useful in labell

1990-04-13

1993-02-02

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

534 10, 534 14, 5303915, A61K 4902, A61K 4300

Patent

active

051836530

ABSTRACT:
Boronic acid adducts of metal dioxime complexes are useful as reagents for labeling proteins and other amine-containing compounds.

REFERENCES:
patent: 4705849 (1987-11-01), Nunn et al.
patent: 4871836 (1989-10-01), Francesconi et al.
W. C. Eckelman et al., "Comparison of Tc-99m and In-111 labeling of conjugated antibodies", Nucl. Med. Biol., 13, 335-343 (1986).
Jurisson et al., Inorg. Chem., 1991, 30, 1820-1827.
E. Deutsch et al., "Technetium Chemistry and Technetium Radiopharmaceuticals", Prog. Inorg. Chem., 30, 75-139, (1983).
C. H. Paik et al., "Transchelation of .sup.99m Tc from low affinity to high affinity sites of antibody", Nucl. Med. Biol., 13, 359-362 (1986).
A. L. Jones et al., "Radiolabeling of Monoclonal Antibody (MAb) fragments with Technetium-99m (Tc-99m) using a One Vial Kit", J. Nucl. Med., 31, 905 (1990).
K. Y. Pak et al., "Stability and Immunoreactivity of Technetium-99m Antibody Fragments by a Direct Labeling Method", J. Nucl. Med., 31, 905 (1990).
A. R. Fritzberg et al., "Specific and stable labeling of antibodies with technetium-99m with a diamide dithiolate chelating agent", Proc. Natl. Acad. Sci., 85, 4024-4029 (1988).
J. Franz et al., "The production of Tc-99m labeled conjugated antibodies using a cyclam based bifunctional chelating agent", Nucl. Med. Biol., 26, 293-299 (1987).
J. R. Morphy et al., "Antibody Labelling with Functionalised Cyclam Macrocycles", J. Chem. Soc. Chem. Commun., 156-158, (1988).
Y. Arano et al., "Synthesis and Evaluation of a New Bifunctional Chelating Agent for 99m-Tc Labeling Proteins: p-Carboxyethylphenylglyoxaldi(N-methylthiosemicarbazone)", Nucl. Med. Biol, 12, 425-430 (1986).
Y. Arano, et al., "Technetium-99m-Labeled Monoclonal Antibody with Preserved Immunoreactivity and High In Vivo Stability", J. Nucl. Med., 28, 1027-1033 (1987).
E. F. Byrne et al., "Technetium-99m bifunctional chelating agent-thiolactone coupling to biomolecules. N.sub.2 S.sub.2 ligand for chelation to Technetium", J. Nucl. Med., 24, p. 126 (1983).
S. Z. Lever et al., "Synthesis of a novel bifunctional chelate designed for labeling proteins with Technetium-99m", Tetrahedron Lett., 29, 3219-3222 (1988).
H. K. Misra et al., "Synthesis of a Novel Diaminodithiol Ligand for Labeling Proteins and Small Molecules with Technetium-99m", Tetrahedron Lett., 30, 1885-1888 (1989).
K. E. Baidoo et al., "Synthesis of a Diaminedithiol Bifunctional Chelating Agent for Incorporation of Technetium-99m into Biomolecules", Bioconjugate Chem., 1, 132-137 (1990).
M. M. Morelock et al., "Metallothionein: A Bifunctional Chelator for the Radiolabeling of Biologically Active Molecules", Experientia, 52 (Supplement: Metallothionein II), 247-253 (1987).
M. M. Morelock et al., "Technetium Metallothioneins", Inorg. Chem., 27, 3137-3140 (1988).
B. A. Brown et al., "Conjugation of Metallothionein to a Murine Monoclonal Antibody", Anal. Biochem., 172, 22-28 (1988).
A. R. Fritzberg, "Advances in .sup.99m Tc-labeling of antibodies", Nuklearmedizin, 26 7-12 (1987).
A. R. Fritzberg et al., "Radiolabeling of antibodies with .sup.99m Tc using N.sub.2 S.sub.2 ligands", J. Nucl. Med., 27, 957-958 (1986).
D. Wilkening et al., "Tc-99m Antibody Labeling with N.sub.3 S and N.sub.2 S.sub.2 Amide Mercaptides: Active Ester Complex Yield and Slide Chain Length", J. Nucl. Med., 29, 815 (1988).
J. R. Morphy et al., "Antibody labeling with Functionalised Cyclam Molecules", J. Chem. Soc. Chem. Commun., 156-158 (1988).
S. Mirzadeh et al., "Radiometal Labeling of Immunoproteins: Covalent Linkage of 2-(4-Isothiocyanatobenzyl)diethylenetriaminepentaacetic Acid Ligands to Immunoglobulin", Bioconjugate Chem., 1, 59-65 (1990).

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