Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-11-21
1992-09-22
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
424 11, 514410, C07D48722
Patent
active
051498014
ABSTRACT:
A compound is described having the structure ##STR1## where R preferably is ##STR2## and most preferably R.sup.3 is a closo-carborane and R.sup.2 is --H, an alkyl or aryl having 1 to about 7 carbon atoms,
REFERENCES:
patent: 4516535 (1985-05-01), Russell, Jr. et al.
patent: 4959356 (1990-09-01), Miura et al.
patent: 4963655 (1990-10-01), Kinder et al.
Barth et al., "Boron Neutron Capture Therapy for Cancer", Scientific American, 100-107, Oct. 1990.
Coderre et al., "Selective Delivery of Boron by the Melanin Precursor Analogue p-Boronphenylalanine to Tumors Other Than Melanoma", Cancer Research, 50, 138-141, Jan. 1, 1990.
Delaney et al., "Photodynamic Therapy of Cancer", Comprehensive Therapy, 14, No. 5, 43-55, May 1988.
Fairchild et al., "In Vitro Determination of Uptake, Retention, Distribution, Biological Efficacy, and Toxicity of Boronated Compounds for Neutron Capture Therapy", Cancer Research, 50, 4860-4865, Aug. 15, 1990.
Fairchild et al., "Optimization of Boron and Neutron Delivery for Neutron Capture Therapy", Pigment Cell Research, 2, 309-318, 1989.
Finkel et al., "Distribution of .sup.10 B After Infusion of Na.sub.2 .sup.10 B.sub.12 H.sub.11 SH Into a patient with Malignant Astrocytoma: Implications for Boron Neutron Capture Therapy", Neurosurgery, 24, No. 1, Jan. 6-11, 1989.
Hawthorne et al., "Preparation of Tumor-Specific Boron Compounds; 1. In Vitro Studies Using Boron-Labeled Antibodies and Elemental Boron as Neutron Targets" Journal of Medicinal Chemistry, 15, No. 5, 449-452, May 1972.
Joel et al., "Pharmacokinetics and Tissue Distribution of the Sulfhydryl Boranes (Monomer and Dimer) in Glioma-Bearing Rats", Strahlenther. Onkol., 165, 167-170, 1989.
Kahl et al., "New Tumor Localizers: Advances in the Use of Low Density Lipoproteins (LDL)" Strahlenther Onkol., 165, 137-139, 1989.
Mishima et al., "Treatment of Malignant Melanoma by Single Thermal Neutron Capture Therapy with Melanoma-Seeking .sup.10 B-Compound", The Lancet, 388-389, Aug. 12, 1989.
Miura et al., "Preparation of Carboranyl Porphyrins for Boron Neutron Capture Therapy", Tetrahedron Letters, 31, No. 16, 2247-2250, 1990.
Sneath et al., "Protein-Binding Polyhedral Boranes.1" Journal of Medicinal Chemistry, 17, No. 8, 796-799, 1974.
Wong et al., "Boron Hydride Derivitives for Neutron Capture Therapy.1", Journal of Medicinal Chemistry, 17, No. 8, 785-791, Aug. 1974.
Fairchild et al., "A Comparison of Particle Radiation Therapy Modalities", Chpt. 2 in Boron-Neutron Capture Therapy for Tumors, H. Hatanaka, editor, Nishimura, 1986.
Hatanaka, "Clinical Experience of Boron-Neutron Capture Therapy for Gliomas-A Comparison with Conventional Chemo-Immuno-Radiotherapy", Chpt. 25 in Boron-Neutron Capture Therapy for Tumors, H. Hatanaka, editor, Nishimura, 1986.
Kahl Stephen B.
Koo Myoung-Seo
Shah Mukund J.
The Regents of the University of California
Venkat Jyothsna
LandOfFree
Boronated porphyrin compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Boronated porphyrin compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Boronated porphyrin compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1069227