Boronated porphyrin compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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424 11, 514410, C07D48722

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active

051498014

ABSTRACT:
A compound is described having the structure ##STR1## where R preferably is ##STR2## and most preferably R.sup.3 is a closo-carborane and R.sup.2 is --H, an alkyl or aryl having 1 to about 7 carbon atoms,

REFERENCES:
patent: 4516535 (1985-05-01), Russell, Jr. et al.
patent: 4959356 (1990-09-01), Miura et al.
patent: 4963655 (1990-10-01), Kinder et al.
Barth et al., "Boron Neutron Capture Therapy for Cancer", Scientific American, 100-107, Oct. 1990.
Coderre et al., "Selective Delivery of Boron by the Melanin Precursor Analogue p-Boronphenylalanine to Tumors Other Than Melanoma", Cancer Research, 50, 138-141, Jan. 1, 1990.
Delaney et al., "Photodynamic Therapy of Cancer", Comprehensive Therapy, 14, No. 5, 43-55, May 1988.
Fairchild et al., "In Vitro Determination of Uptake, Retention, Distribution, Biological Efficacy, and Toxicity of Boronated Compounds for Neutron Capture Therapy", Cancer Research, 50, 4860-4865, Aug. 15, 1990.
Fairchild et al., "Optimization of Boron and Neutron Delivery for Neutron Capture Therapy", Pigment Cell Research, 2, 309-318, 1989.
Finkel et al., "Distribution of .sup.10 B After Infusion of Na.sub.2 .sup.10 B.sub.12 H.sub.11 SH Into a patient with Malignant Astrocytoma: Implications for Boron Neutron Capture Therapy", Neurosurgery, 24, No. 1, Jan. 6-11, 1989.
Hawthorne et al., "Preparation of Tumor-Specific Boron Compounds; 1. In Vitro Studies Using Boron-Labeled Antibodies and Elemental Boron as Neutron Targets" Journal of Medicinal Chemistry, 15, No. 5, 449-452, May 1972.
Joel et al., "Pharmacokinetics and Tissue Distribution of the Sulfhydryl Boranes (Monomer and Dimer) in Glioma-Bearing Rats", Strahlenther. Onkol., 165, 167-170, 1989.
Kahl et al., "New Tumor Localizers: Advances in the Use of Low Density Lipoproteins (LDL)" Strahlenther Onkol., 165, 137-139, 1989.
Mishima et al., "Treatment of Malignant Melanoma by Single Thermal Neutron Capture Therapy with Melanoma-Seeking .sup.10 B-Compound", The Lancet, 388-389, Aug. 12, 1989.
Miura et al., "Preparation of Carboranyl Porphyrins for Boron Neutron Capture Therapy", Tetrahedron Letters, 31, No. 16, 2247-2250, 1990.
Sneath et al., "Protein-Binding Polyhedral Boranes.1" Journal of Medicinal Chemistry, 17, No. 8, 796-799, 1974.
Wong et al., "Boron Hydride Derivitives for Neutron Capture Therapy.1", Journal of Medicinal Chemistry, 17, No. 8, 785-791, Aug. 1974.
Fairchild et al., "A Comparison of Particle Radiation Therapy Modalities", Chpt. 2 in Boron-Neutron Capture Therapy for Tumors, H. Hatanaka, editor, Nishimura, 1986.
Hatanaka, "Clinical Experience of Boron-Neutron Capture Therapy for Gliomas-A Comparison with Conventional Chemo-Immuno-Radiotherapy", Chpt. 25 in Boron-Neutron Capture Therapy for Tumors, H. Hatanaka, editor, Nishimura, 1986.

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