Boronated nucleoside, nucleotide and oligonucleotide compounds,

Details Boronated nucleoside, nucleotide and oligonucleotide compounds, Boronated nucleoside, nucleotide and oligonucleotide compounds,

1989-12-20

1992-07-14

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 46, 514 47, 514 48, 514 49, 514 50, 514 51, 514 64, 536 23, 536 24, 536 27, 536 28, 536 29, 536 171, A61K 3100, C07H 1900, C07H 2100

Patent

active

051303027

ABSTRACT:
A novel class of pharmaceutically active boronated nucleosides are provided. The nucleosides are boronated at a ring nitrogen of the purine or pyrimidine or analogues thereof. Also provided are phosphate esters of these nucleosides and oligomers thereof. Methods of making and using the boronated nucleosides are also disclosed.

REFERENCES:
Schinazi et al., "Boron Compounds Suitable for Neutron Capture Therapy for . . . Cancer", National Cancer Institute Workshop, May 3-4, 1988.
Cover Sheet for the North Carolina Biotechnology Center Competitive Grants Program. Project Entitled "Boron Nucleic Acids".
Cover Sheet for the North Carolina Biotechnology Center Economic Development Program. Project Entitled "Boronated Nucleosides".
"A Suitable Case for Irradiation", Borax Review, No. 3, 7 (1988).
Schinazi, R. et al., "Rational Design of Pyrimidines and Nucleosides for Neutron Capture Therapy, " National Cancer Institute Workshop (May, 1988) (Pub. by National Cancer Institute), pp. 1-11.
Kabalka, G. et al., "Boron-11 MRI and MRS of Intact Animals Infused with a Boron Neutron Capture Agent," Magnetic Resonance in Medicine 8, 231 (1988).

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