Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-03-11
2010-11-30
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07842682
ABSTRACT:
The present invention relates to meta 1-phthalocyanines bearing at least a group containing boron isotopes11B or10B, covalently bound to the peripheral positions of meta 1-phthalocyanine nucleus; moreover it refers to the processes for their preparation, the pharmaceutical compositions comprising them and their use for the treatment of neoplastic and dysplastic pathologies.
REFERENCES:
patent: 3730950 (1973-05-01), Barnes et al.
patent: 0 906 758 (1999-04-01), None
Pinedo et al., “Translational Research . . . ”, The Oncologist 2000; 5(suppl 1); 1-2.
McMahon, G., “VEGF Receptor Signalin in Tumor Angiogenisis”., The Oncologist 2000; 5(suppl1); 3-10.
Alam, F. et al., “Boron compounds for neutron capture therapy,” XP002291250 retrieved from STN Database Accession No. 1990:455131; Database CHEMABS [Online] Chemicals Abstract Service, Columbus, Ohio US; 1990, Abstract.
Fabris, C. et al., “Photosynthesizing properties of a boronated phthalocyanine: studies at the molecular and cellular level,”Journal of Photochemistry and Photobiology B: Biology2001; 64(1):1-7.
Kahl, S. B. et al., “Synthesis and Characterization of a Boronated Metallophthalocyanine for Boron Neutron Capture Therapy,”Inorg. Chem.1996; 35:3878-3880.
Plater, M.J. et al., “Synthesis of soluble halogenated aryloxy substituted indium phthalocyanines,”J. Chem. Soc., Perkin Trans. I2002; 91-96.
Vladimir I. Bregadze et al., “Polyhedral boron derivatives of porphyrins and phthalocyanines,”Journal of Porphyrins and Phthalocyanines, 2001; 5: 767-78.
John S. Sill et al., “Selective tumor kill of cerebral glioma by photodynamic therapy using a boronated porphyrin photosensitizer,”Proc. Natl. Acad. Sci. USA, vol. 92, pp. 12126-12130, Dec. 1995.
R. Spryshkova et al., “Biodistribution Study of Novel Dodecaborate-Phthalocyanines in the B-16 Mouse Melanoma Model,”Frontiers in Neutron Capture Therapy, edited by Hawthorne et al., Kluwer Academic, Plenum Publishers, New York 2001, pp. 1027-1032.
M. Graça H. Vicente, “Syntheses of carbon-carbon linked carboranylated porphyrins for boron neutron capture therapy of cancer,”Tetrahedron Letters, 41: 7623-7627 (2000).
Friso, E. et al., “A novel10B-enriched carboranyl-containing phthalocyanine as a radio- and photo-sensitising agent for boron neutron capture therapy and photodynamic therapy of tumours: in vitro and in vivo studies,”Photochem. Photobiol. Sci.2006; 5:39-50.
Mody, T., “Pharmaceutical development and medical applications of porphyrin-type macrocycles,”Journal of Porphyrins and Phthalocyanines2000; 4:362-367.
Chiti Giacomo
Dei Donata
Fabris Clara
Giuntini Francesca
Jori Giulio
L. Molteni & C. Dei Fratelli Alitti
Ward Paul V.
Wilson James O.
Wolf Greenfield & Sacks P.C.
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