Boronated compounds

Details Boronated compounds Boronated compounds

1992-07-07

1994-11-08

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514261, 514269, 514824, 514825, 514886, 544242, 544264, A61K 31505, A61K 3152, C07D23900, C07D47300

Patent

active

053627326

ABSTRACT:
A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds are boronated at the ring nitrogen of the purine or pyrimidine base, or at a 2', 3' or 5' amino substituent of the nucleoside sugar.

REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
patent: 5130302 (1992-07-01), Spielvogel et al.
"Boron-Containing Nucleic Acids: Synthesis of Cyanoborane Adducts of 2'-Deoxynucleosides"; J. Am. Chem. Soc.; Sood, et al.; 1989, 111, pp. 9234-9235.
"From Boron Analogues of Amino Acids to Boronated DNA: Potential New Pharmaceuticals and Neutron Capture Agents"; Pure & Appl. Chem., Spielvogel, et al.; vol. 63, No. 3, pp. 415-418, 1991.
"Boron-Containing Nucleic Acids. 2..sup.1 Synthesis of Oligodeoxynucleoside Boranophosphates"; J. Am. Chem. Soc.; Sood, et al.; 1990, pp. 9000-9001.
"The Synthesis and Antineoplastic Activity of 2'-Deoxynucleoside-cyanoboranes in Murine and Human Culture Cells"; Sood, et al.; Anticancer Research; 12: pp. 335-344 (1992).

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