Boronated compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 41, 536 171, 536 221, 536 2671, 536 268, 536 271, 536 2721, 536 274, 536 276, 536 2763, 536 278, 536 2781, 536 281, 536 285, 536 2853, 536 2854, C07H 100, C07H 2300

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active

056590270

ABSTRACT:
A novel class of pharmaceutically active boronated compounds are provided. The boronated compounds include boronated purine and pyrimidine bases and boronated nucleosides, as well as phosphate esters and oligomers thereof. The compounds are boronated at the ring nitrogen of the purine or pyrimidine base, or at a 2', 3' or 5' amino substituent of the nucleoside sugar.

REFERENCES:
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patent: 5130302 (1992-07-01), Spievogel et al.
patent: 5362732 (1994-11-01), Spielvogel et al.
"Boron-Containing Nucleic Acids: Synthesis of Cyanoborane Adducts of 2'-Deoxynucleosides"; J. Am. Chem Soc.; Sood, et al.; 1989, 11 pp. 9234-235.
"From Boron Analogues of Amino Acids to Boronated DNA: Potential New Pharmaceuticals and Neutron Capture Agents"; Pure & Appl. Chem., Spielvogel, et al.; vol. 63, No. 3, pp. 415-418, 1991.
"Boron-Containing Nucleic Acids.2..sup.1 Synthesis of Oligodeoxynucleoside Boranophosphates"; J. Amer. Chem. Soc.; Sood, et al.; 1990, 112 pp. 9000-9001.
"The Synthesis and Antineoplastic Activity of 2'-Deoxynucleoside-cyanoboranes in Murine and Human Culture Cells"; Sood, et al.; Anticancer Research; 12 pp. 335-344 (1992).

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